Evidence map›Paper›PMID 36532457›Full record

ReviewFrontiers in microbiology2022

Antifungal metabolites, their novel sources, and targets to combat drug resistance.

Megha Choudhary, Vijay Kumar, Bindu Naik, Ankit Verma, Per Erik Joakim Saris, Vivek Kumar, Sanjay Gupta

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. A Novel Skeleton Compound fromMicroorganisms · 2026
    Article
  2. Article
  3. Targeting Fructosamine Oxidase (Amadoriase II) inCurrent medicinal chemistry · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Megha ChoudharyHimalayan School of Biosciences, Swami Rama Himalayan University, Dehradun, India.
Vijay KumarHimalayan School of Biosciences, Swami Rama Himalayan University, Dehradun, India.
Bindu NaikDepartment of Life Sciences (Food Technology & Nutrition), Graphic Era (Deemed to be University), Dehradun, India.
Ankit VermaHimalayan School of Biosciences, Swami Rama Himalayan University, Dehradun, India.
Per Erik Joakim SarisDepartment of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Helsinki, Finland.
Vivek KumarHimalayan School of Biosciences, Swami Rama Himalayan University, Dehradun, India.
Sanjay GuptaHimalayan School of Biosciences, Swami Rama Himalayan University, Dehradun, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive antibiotic prescriptions as well as their misuse in agriculture are the main causes of antimicrobial resistance which poses a growing threat to public health. It necessitates the search for novel chemicals to combat drug resistance. Since ancient times, naturally occurring medicines have been employed and the enormous variety of bioactive chemicals found in nature has long served as an inspiration for researchers looking for possible therapeutics. Secondary metabolites from microorganisms, particularly those from actinomycetes, have made it incredibly easy to find new molecules. Different actinomycetes species account for more than 70% of naturally generated antibiotics currently used in medicine, and they also produce a variety of secondary metabolites, including pigments, enzymes, and anti-inflammatory compounds. They continue to be a crucial source of fresh chemical diversity and a crucial component of drug discovery. This review summarizes some uncommon sources of antifungal metabolites and highlights the importance of further research on these unusual habitats as a source of novel antimicrobial molecules.

Indexed as

antifungal agentsdrug resistantnovel targetspeptidesunusual habitats

Identifiers

PMID36532457
PMCPMC9755354

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.