ArticleNeurobiology of stress2022
Maternal adverse childhood experiences and infant subcortical brain volume.
Article in Neurobiology of stress, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial for maternal prenatal depression.Nature communications · 2026Trial
- Postnatal distress, neonatal cerebellar myelination and neurodevelopmental outcomes at 18 months.Molecular psychiatry · 2026Article
- Maternal Childhood Neglect is Linked to Greater Infant Cortisol Levels and Larger Infant Limbic Volumes.Child maltreatment · 2026Article
- The Impact of Childhood Trauma on Neuropsychological Disorders and Its Intergenerational Transmission Mechanisms.Behavioral sciences (Basel, Switzerland) · 2026Review
- Maternal Childhood Maltreatment, Development of Amygdala Volume, and Anxiety Symptoms in Offspring.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Neonatal striatal volume is associated with infant anhedonia.Journal of affective disorders · 2026Article
- Early Life Adversity and Disordered Eating: Cognitive and Neural Mechanisms.Behavioral sciences (Basel, Switzerland) · 2025Review
- Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents.Biological psychiatry global open science · 2025Article
- The Intergenerational Impact of Maternal Childhood Adversity on Child Behavior and Neurodevelopment: The Healthy MiNDS Protocol.International journal of methods in psychiatric research · 2025Article
- The association between prenatal maternal anxiety, infant brain volumes, and temperament during the COVID-19 pandemic.Translational psychiatry · 2025Article
- Is neglect the first form of threat?Attachment & human development · 2025Review
- Association between prenatal maternal sleep quality, neonatal uncinate fasciculus white matter, and infant negative emotionality.EBioMedicine · 2024Article
- Leveraging the science of early life predictability to inform policies promoting child health.Developmental cognitive neuroscience · 2024Review
- Stress in pregnancy - Implications for fetal BDNF in amniotic fluid at birth.Neurobiology of stress · 2024Article
- Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- [Research progress on the mechanism of the impact of maternal childhood trauma on intergenerational transmission].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Maternal adverse childhood experiences on child growth and development in rural Pakistan: An observational cohort study.PLOS global public health · 2023Article
- Transmit Radiant Individuality to Offspring (TRIO) study: investigating intergenerational transmission effects on brain development.Frontiers in psychiatry · 2023Article
- Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume.Developmental cognitive neuroscience · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Background: A large body of research supports the deleterious effects of adverse childhood experiences (ACEs) on disease susceptibility and health for both the exposed individual and the next generation. It is likely that there is an intergenerational transmission of risk from mother to child; however, the mechanisms through which such risk is conferred remain unknown. The current study evaluated the association between maternal ACEs, neonatal brain development of the amygdala and hippocampus, and later infant negative emotionality at six months of age. Methods: The sample included 85 mother-infant dyads (44 female infants) from a longitudinal study. Maternal ACEs were assessed with the Adverse Childhood Experiences Questionnaire (ACE-Q) and neonatal hippocampal and amygdala volume was assessed using structural magnetic resonance imaging (MRI). Infant negative emotionality was assessed at 6 months using the Infant Behavior Questionnaire (IBQ). Results: Multivariate analyses demonstrated that maternal ACEs were associated with bilateral amygdala volume ( Conclusions: Maternal ACEs are associated with both newborn amygdala volume and subsequent infant negative emotionality. These findings linking maternal adverse childhood experiences and infant brain development and temperament provide evidence to support the intergenerational transmission of adversity from mother to child.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.