Evidence map›Paper›PMID 36532359›Full record

ArticleJournal of the Endocrine Society2022

Case-control Investigation of Previously Undiagnosed Diabetes in the Critically Ill.

James S Krinsley, Gregory Roberts, Michael Brownlee, Michael Schwartz, Jean-Charles Preiser, Peter Rule, Yu Wang, Joseph Bahgat, Guillermo E Umpierrez, Irl B Hirsch

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

James S KrinsleyDepartment of Medicine, Stamford Hospital and Columbia Vagelos Columbia College of Physicians and Surgeons, Stamford, CT 06902, USA.ORCID https://orcid.org/0000-0002-3763-5857
Gregory RobertsDepartment of Pharmacology, Flinders Medical Centre, Bedford Park, SA 5042, Australia.
Michael BrownleeDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Michael SchwartzDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
Jean-Charles PreiserDepartment of Intensive Care, Erasme University Hospital, Brussels 1070, Belgium.
Peter RulePRI Consultants, Los Altos Hills, CA 94024, USA.
Yu WangDepartment of Medicine, Stamford Hospital and Columbia Vagelos Columbia College of Physicians and Surgeons, Stamford, CT 06902, USA.
Joseph BahgatDepartment of Medicine, Stamford Hospital and Columbia Vagelos Columbia College of Physicians and Surgeons, Stamford, CT 06902, USA.
Guillermo E UmpierrezDepartment of Medicine, Emory University School of Medicine, Atlanta, GA 30307, USA.
Irl B HirschDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
Stamford Hospital · USUniversity of Washington · USAlbert Einstein College of Medicine · USEmory University · USErasmus Hospital · BEFlinders Medical Centre · AU

Funding

PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
Novel Brain Mechanisms Controlling Glucose HomeostasisR01DK083042 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2008 to 2025
$7.6M
NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK083042
6 · The paper itself

Abstract

Context: The outcome of patients requiring intensive care can be influenced by the presence of previously undiagnosed diabetes (undiagDM). Objective: This work aimed to define the clinical characteristics, glucose control metrics, and outcomes of patients admitted to the intensive care unit (ICU) with undiagDM, and compare these to patients with known DM (DM). Methods: This case-control investigation compared undiagDM (glycated hemoglobin A Results: Of 5567 patients 294 (5.3%) were undiagDM. UndiagDM had lower ICU mean BG ( Conclusion: These data suggest that DM patients may develop tolerance to hyperglycemia that occurs during critical illness, a protective mechanism not observed in undiagDM, for whom hyperglycemia remains strongly associated with higher risk of mortality. These results may shed light on the natural history of diabetes.

Indexed as

critically illdiabetesglycemic ratiohyperglycemiahypoglycemiamortality

Identifiers

PMID36532359
PMCPMC9753064
OpenAlexW4309918133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.