Evidence map›Paper›PMID 36532344›Full record

ArticleFrontiers in veterinary science2022

Predicting cross-protection against foot-and-mouth disease virus strains by serology after vaccination.

Simon Gubbins, David J Paton, Aldo Dekker, Anna B Ludi, Ginette Wilsden, Clare F J Browning, Michael Eschbaumer, Jamie Barnabei, Hernando Duque, Lisa L Pauszek and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Simon GubbinsThe Pirbright Institute, Pirbright, United Kingdom.
David J PatonThe Pirbright Institute, Pirbright, United Kingdom.
Aldo DekkerLaboratory Vesicular Diseases, Department of Virology and Molecular Biology, Wageningen Bioveterinary Research, Lelystad, Netherlands.
Anna B LudiThe Pirbright Institute, Pirbright, United Kingdom.
Ginette WilsdenThe Pirbright Institute, Pirbright, United Kingdom.
Clare F J BrowningThe Pirbright Institute, Pirbright, United Kingdom.
Michael EschbaumerInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald, Germany.
Jamie BarnabeiPlum Island Animal Disease Center, Greenport, NY, United States.
Hernando DuquePlum Island Animal Disease Center, Greenport, NY, United States.
Lisa L PauszekPlum Island Animal Disease Center, Greenport, NY, United States.
Donald P KingThe Pirbright Institute, Pirbright, United Kingdom.
The Pirbright Institute · GBPlum Island Animal Disease Center · USFriedrich-Loeffler-Institut · DEWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serology is widely used to predict whether vaccinated individuals and populations will be protected against infectious diseases, including foot-and-mouth disease (FMD), which affects cloven-hoofed animals. Neutralising antibody titres to FMD challenge viruses correlate to protection against FMD, for vaccinated cattle that are infected with the same strain as in the vaccine (homologous protection). Similar relationships exist for cross-strain protection between different vaccine and challenge viruses, although much less data are available for these heterologous studies. Poor inter-laboratory reproducibility of the virus neutralisation test (VNT) also hampers comparisons between studies. Therefore, day-of-challenge sera (

Indexed as

foot-and-mouth diseaseimmune correlatepost-vaccination monitoringpredicting cross-protectionserologyvaccinationvirus neutralising antibody

Identifiers

PMID36532344
PMCPMC9751447
OpenAlexW4310523509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.