ArticleFrontiers in neuroscience2022
Characterisation of parasympathetic ascending nerves in human colon.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- Extrinsic Innervation of Myenteric Plexus of Human Large Intestine Via Colonic Nerves.Cellular and molecular gastroenterology and hepatology · 2025Article
- Article
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Authors and funding
8 authors.
Funding
Abstract
Background: In the human large bowel, sacral parasympathetic nerves arise from S2 to S4, project to the pelvic plexus ("hypogastric plexus") and have post-ganglionic axons entering the large bowel near the rectosigmoid junction. They then run long distances orally or aborally within the bowel wall forming "ascending nerves" or "shunt fascicles" running in the plane of the myenteric plexus. They form bundles of nerve fibres that can be distinguished from the myenteric plexus by their straight orientation, tendency not to merge with myenteric ganglia and greater width. Aim: To identify reliable marker(s) to distinguish these bundles of ascending nerves from other extrinsic and intrinsic nerves in human colon. Methods: Human colonic segments were obtained with informed consent, from adult patients undergoing elective surgery ( Results: The rectosigmoid and rectal specimens had 6-11 ascending nerves spaced around their circumference. Distal colon specimens typically had 1-3 ascending nerves, with one located near the mesenteric taenia coli. No ascending nerves were observed in ascending colon specimens. GLUT1 antisera labelled both sympathetic lumbar colonic nerves and ascending nerves in the gut wall. Lumbar colonic nerves joined the myenteric plexus and quickly lost GLUT1 labelling, whereas GLUT1 staining labelled parasympathetic ascending nerves over many centimetres. Conclusion: Ascending nerves can be distinguished in the colorectum of humans using GLUT1 labelling combined with NF200.
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