ReviewFrontiers in cell and developmental biology2022
Cerebellar mutism syndrome: From pathophysiology to rehabilitation.
Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Pre-operative and intra-operative risk factors of post-operative cerebellar mutism syndrome in pediatric patients undergoing posterior fossa tumor surgery: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- Neurological, Neuropsychological, and Social Outcomes in Pediatric Patients Diagnosed With Cerebellar Mutism Syndrome: A Systematic Review.Pediatric blood & cancer · 2025Pooled it
- Cerebellar mutism syndrome caused by bilateral cerebellar hemorrhage in adults: a case report and review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Frequency-dependent cerebellar circuits independently gate social vocalizations and movement.iScience · 2026Article
- Suboccipital transhorizontal fissure approach for a deep-seated pediatric cerebellar tumor: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Frequency-dependent cerebellar circuits independently gate social vocalizations and movement.bioRxiv : the preprint server for biology · 2026Article
- Neuroendoscopy improves operability and reduces hazardous vermian manipulation during the telovelar approach to the fourth ventricle's floor: an anatomical study.Neurosurgical review · 2026Article
- Article
- A study protocol for international consensus guidelines on music therapy for paediatric posterior fossa syndrome.PloS one · 2026Article
- Does the surgical route matter in cerebellar mutism syndrome? Comparing transvermian and telovelar approaches for pediatric posterior fossa tumors.Brain & spine · 2026Review
- Association between perioperative factors and the occurrence of postoperative cerebellar mutism syndrome in children.Frontiers in neurology · 2026Article
- Feeding and swallowing function and dysphagia risk in children with posterior fossa tumors: a preliminary Italian cohort study.Frontiers in oncology · 2026Article
- Fractal dimension as a predictive biomarker for tumor grade and cerebellar mutism syndrome in pediatric posterior fossa tumors.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Multi-parametric [European journal of nuclear medicine and molecular imaging · 2025Article
- A predictive model for cerebellar mutism syndrome based on lesion map in children with medulloblastoma.European radiology · 2025Article
- Cerebellar Mutism/Posterior Fossa Syndrome Following Resection of Posterior Fossa Tumor in Pediatric Patients: Assessing Pathophysiology, Risk Factors, and Neuroradiographic Features.Asian journal of neurosurgery · 2025Article
- Integrating Radiomics and Lesion Mapping for Cerebellar Mutism Syndrome Prediction.Children (Basel, Switzerland) · 2025Article
- Involvement of the Cerebellar Peduncles inInternational journal of molecular sciences · 2025Review
- Different diseases, same circuits: lessons from rare and overlooked causes of disorders of consciousness.Brain communications · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebellar mutism syndrome (CMS) is a common complication following surgical resection of childhood tumors arising in the posterior fossa. Alteration of linguistic production, up to muteness and emotional lability, generally reported at least 24 h after the intervention, is the hallmark of post-operative CMS. Other associated traits include hypotonia and other cerebellar motor signs, cerebellar cognitive-affective syndrome, motor deficits from the involvement of the long pathways, and cranial neuropathies. Recovery usually takes 6 months, but most children are burdened with long-term residual deficits. The pathogenic mechanism is likely due to the damage occurring to the proximal efferent cerebellar pathway, including the dentate nucleus, the superior cerebellar peduncle, and its decussation in the mesencephalic tegmentum. Proven risk factors include brain stem invasion, diagnosis of medulloblastoma, midline localization, tumor size, invasion of the fourth ventricle, invasion of the superior cerebellar peduncle, left-handedness, and incision of the vermis. Currently, rehabilitation is the cornerstone of the treatment of patients with cerebellar mutism syndrome, and it must consider the three main impaired domains, namely speech, cognition/behavior, and movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.