Evidence map›Paper›PMID 36531853›Full record

ArticleThe Neurohospitalist2023

Leptomeningeal Disease Secondary to Thr60Ala Transthyretin Amyloidosis: Case Report and Review of the Literature.

Nathan Carberry, Sun Yu, Raisy N Fayerman, Rachelle Dugue, Michael Miller, Kurenai Tanji, Tarini Goyal, Peter Canoll, Thomas H Brannagan

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Neurohospitalist, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Liver-directed drugs for transthyretin-mediated amyloidosis.Journal of the peripheral nervous system : JPNS · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nathan CarberryDepartment of Neurology, Neuromuscular Division, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID https://orcid.org/0000-0001-9194-3247
Sun YuDepartment of Pathology, Columbia University Irving Medical Center, New York, NY, USA.
Raisy N FayermanDepartment of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
Rachelle DugueDepartment of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.ORCID https://orcid.org/0000-0002-5179-4424
Michael MillerDepartment of Pathology, Columbia University Irving Medical Center, New York, NY, USA.ORCID https://orcid.org/0000-0002-6350-5706
Kurenai TanjiDepartment of Pathology, Columbia University Irving Medical Center, New York, NY, USA.
Tarini GoyalDepartment of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.ORCID https://orcid.org/0000-0002-4436-3909
Peter CanollDepartment of Pathology, Columbia University Irving Medical Center, New York, NY, USA.
Thomas H BrannaganDepartment of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
Columbia University Irving Medical Center · USUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 31-year-old woman with transthyretin (TTR) amyloidosis secondary to a Thr60Ala mutation developed recurrent stroke-like episodes with fluctuating mental status. Evaluation for stroke and seizures was unrevealing. She was found to have leptomeningeal contrast enhancement on magnetic resonance imaging, which was confirmed to be CNS TTR amyloidosis on histopathology following brain and dura biopsy. While leptomeningeal disease has rarely been known to be associated with TTR amyloidosis, this is the first documented case of leptomeningeal disease secondary to a Thr60Ala mutation in the TTR gene. A literature review of TTR amyloidosis is presented with special focus on the treatment of leptomeningeal TTR amyloidosis.

Indexed as

CNS involvementleptomeningeal diseaseplateau wavesstroke-like episodestransthyretin amyloidosisTTR amyloidosis

Identifiers

PMID36531853
PMCPMC9755614
OpenAlexW4303983186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.