Evidence map›Paper›PMID 36531583›Full record

ArticleOphthalmology science2022

Evaluation of an Artificial Intelligence System for Retinopathy of Prematurity Screening in Nepal and Mongolia.

Emily Cole, Nita G Valikodath, Tala Al-Khaled, Sanyam Bajimaya, Sagun Kc, Tsengelmaa Chuluunbat, Bayalag Munkhuu, Karyn E Jonas, Chimgee Chuluunkhuu, Leslie D MacKeen and 10 more

Abstract read
In one paragraph

Article in Ophthalmology science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Artificial intelligence in ophthalmology clinical trials: a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  4. Review
  5. Artificial intelligence in ophthalmology: opportunities, challenges, and ethical considerations.Medical hypothesis, discovery & innovation ophthalmology journal · 2025
    Review
  6. Article
  7. Review
  8. A review on retinopathy of prematurity.Medical hypothesis, discovery & innovation ophthalmology journal · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Emily ColeDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, Illinois.
Nita G ValikodathDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, Illinois.
Tala Al-KhaledDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, Illinois.
Sanyam BajimayaTilganga Institute of Ophthalmology, Kathmandu, Nepal.
Sagun KcHelen Keller International, Kathmandu, Nepal.
Tsengelmaa ChuluunbatNational Center for Maternal and Child Health, Ulaanbaatar, Mongolia.
Bayalag MunkhuuNational Center for Maternal and Child Health, Ulaanbaatar, Mongolia.
Karyn E JonasDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, Illinois.
Chimgee ChuluunkhuuOrbis International, New York, New York.
Leslie D MacKeenThe Hospital for Sick Children, Toronto, Canada.
Vivien YapDepartment of Pediatrics, Weill Cornell Medical College, New York, New York.
Joelle HallakDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, Illinois.
Susan OstmoDepartment of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Wei-Chi WuChang Gung Memorial Hospital, Taoyuan, Taiwan, and Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Aaron S CoynerDepartment of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Praveer SinghHarvard Medical School, Boston, Massachusetts.
Jayashree Kalpathy-CramerHarvard Medical School, Boston, Massachusetts.
Michael F ChiangNational Eye Institute, National Institutes of Health, Bethesda, Maryland.
J Peter CampbellDepartment of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
R V Paul ChanDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, Illinois.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate the performance of a deep learning (DL) algorithm for retinopathy of prematurity (ROP) screening in Nepal and Mongolia. Design: Retrospective analysis of prospectively collected clinical data. Participants: Clinical information and fundus images were obtained from infants in 2 ROP screening programs in Nepal and Mongolia. Methods: Fundus images were obtained using the Forus 3nethra neo (Forus Health) in Nepal and the RetCam Portable (Natus Medical, Inc.) in Mongolia. The overall severity of ROP was determined from the medical record using the International Classification of ROP (ICROP). The presence of plus disease was determined independently in each image using a reference standard diagnosis. The Imaging and Informatics for ROP (i-ROP) DL algorithm was trained on images from the RetCam to classify plus disease and to assign a vascular severity score (VSS) from 1 through 9. Main Outcome Measures: Area under the receiver operating characteristic curve and area under the precision-recall curve for the presence of plus disease or type 1 ROP and association between VSS and ICROP disease category. Results: The prevalence of type 1 ROP was found to be higher in Mongolia (14.0%) than in Nepal (2.2%; Conclusions: These data provide preliminary evidence of the effectiveness of the i-ROP DL algorithm for ROP screening in neonatal populations in Nepal and Mongolia using multiple camera systems and are useful for consideration in future clinical implementation of artificial intelligence-based ROP screening in low- and middle-income countries.

Indexed as

Artificial intelligenceBW, birth weightDeep learningDL, deep learningGA, gestational ageICROP, International Classification of Retinopathy of PrematurityIQR, interquartile rangei-ROP, Imaging and Informatics for Retinopathy of PrematurityLMIC, low- and middle-income countryMongoliaNepalRetinopathy of prematurityROP, retinopathy of prematurityRSD, reference standard diagnosisTR, treatment-requiringVSS, vascular severity score

Identifiers

PMID36531583
PMCPMC9754980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.