ReviewMediterranean journal of rheumatology2022
Time to Deal with Rheumatoid Cachexia: Prevalence, Diagnostic Criteria, Treatment Effects and Evidence for Management.
Review in Mediterranean journal of rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06400316 (Preventing Muscle Wasting During Rheumatoid Arthritis Flares), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventing Muscle Wasting During Rheumatoid Arthritis Flares: A Randomised Controlled Trial
Who cites it
17 citing papers in PubMed, 16 citations in OpenAlex.
- Consumption of ultra-processed foods among patients with rheumatic diseases: a cross-sectional study and validation of the short screening questionnaire of highly processed food consumption (sQ-HPF) in the Greek language.Rheumatology international · 2026Article
- Ultrasound viscoelasticity and attenuation imaging for rheumatoid arthritis-associated muscle quality changes: a clinical transcriptomic study.Clinical rheumatology · 2026Article
- Attenuation of Cardiac Dysfunction in the Collagen-Induced Arthritis Mouse Model Mediated by a Reactive Aldehyde Species Inhibitor.International journal of molecular sciences · 2026Article
- No Differences in Malnutrition Status and Prognostic Nutrition Index Between Female Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Case-Control Study.Mediterranean journal of rheumatology · 2026Article
- Systemic lupus erythematosus is associated with an increased risk for orthorexia nervosa: a cross-sectional study.Rheumatology international · 2026Article
- Prevalence of malnutrition using the GLIM criteria and the subjective global assessment among patients with rheumatic and musculoskeletal diseases.Clinical rheumatology · 2026Article
- Anti-arthritic appraisal of Acorus calamus L. extracts in complete Freund's adjuvant‑induced arthritic Wistar rats via regulating inflammatory cytokines and OPG/RANKL pathway.Inflammopharmacology · 2026Article
- Transcending aging: disease specificity, assessment challenges, and management strategies for rheumatoid arthritis-related sarcopenia.Frontiers in medicine · 2026Review
- Frequency of dysphagia among patients submitted to a rheumatology department: a cross-sectional analysis based on the EAT-10 questionnaire.Rheumatology international · 2025Article
- Ocimene mitigates pyroptosis through TLR4/NLRP3-mediated mechanisms in CFA-induced inflammation.Inflammopharmacology · 2025Article
- Sarcopenia in Rheumatic Diseases: A Hidden Issue of Concern.Diseases (Basel, Switzerland) · 2025Review
- Screening and diagnosis of sarcopenia in rheumatic and musculoskeletal diseases: findings from a cross-sectional study.Rheumatology international · 2025Article
- Role of Myostatin in Rheumatoid Arthritis: A Review of the Clinical Impact.Diagnostics (Basel, Switzerland) · 2024Review
- Energy Regulation in Inflammatory Sarcopenia by the Purinergic System.International journal of molecular sciences · 2023Review
- Curcumin Co-Encapsulation Potentiates Anti-Arthritic Efficacy of Meloxicam Biodegradable Nanoparticles in Adjuvant-Induced Arthritis Animal Model.Biomedicines · 2023Article
- Fly Me to the Immune: Immunonutrition in Rheumatic Diseases.Mediterranean journal of rheumatology · 2023Article
- Ceramides in Autoimmune Rheumatic Diseases: Existing Evidence and Therapeutic Considerations for Diet as an Anticeramide Treatment.Nutrients · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cachexia is an early result of rheumatoid arthritis (RA) (rheumatoid cachexia, RC), characterised mainly by involuntary loss of fat-free mass. RC is apparent in 1-67% of patients with RA, depending on the diagnostic criteria applied and the method used for the assessment of body composition. RC is associated with increased inflammation and disability, lower health perception, and greater mortality risk. These changes in body composition are driven by the inflammation process, the low levels of physical activity, the underlying testosterone deficiency and hypogonadism, and the pharmacotherapy required for RA. Chronic inflammation enhances resting energy expenditure as a response to stress, inducing an energy deficit, further propelling protein turnover. The use of corticosteroids and tumour necrosis factor α (TNF-α) inhibitors tend to increase fat accumulation, whereas other disease-modifying antirheumatic drugs (DMARDs) appear to induce increments in fat-free mass. The present review presents all information regarding the prevalence of RC, diagnostic criteria, and comorbidities, as well as the effects of pharmacotherapy and medical nutrition therapy on body composition of patients with RA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.