Evidence map›Paper›PMID 36531331›Full record

ArticleFrontiers in chemistry2022

Anticancer effect of zinc oxide nanoparticles prepared by varying entry time of ion carriers against A431 skin cancer cells

Albandri Yousef Aljohar, Ghazala Muteeb, Qamar Zia, Sahabjada Siddiqui, Mohammad Aatif, Mohd Farhan, Mohd Farhan Khan, Abdulrahman Alsultan, Azfar Jamal, Adil Alshoaibi and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  6. Development of topical silver nano gel formulation of Bixin: Characterization, and evaluation of anticancer activity.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Albandri Yousef AljoharDepartment of Clinical Nutrition, College of Applied Medical Science, King Faisal University, Al Ahsa, Saudi Arabia.
Ghazala MuteebDepartment of Nursing, College of Applied Medical Science, King Faisal University, Al Ahsa, Saudi Arabia.
Qamar ZiaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majma'ah, Saudi Arabia.
Sahabjada SiddiquiDepartment of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, India.
Mohammad AatifDepartment of Public Health, College of Applied Medical Science, King Faisal University, Al Ahsa, Saudi Arabia.
Mohd FarhanDepartment of Basic Sciences, King Faisal University, Al Ahsa, Saudi Arabia.
Mohd Farhan KhanFaculty of Science, Gagan College of Management & Technology, Aligarh, India.
Abdulrahman AlsultanDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al Ahsa, Saudi Arabia.
Azfar JamalDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majma'ah, Saudi Arabia.
Adil AlshoaibiDepartment of Physics, College of Science, King Faisal University, Al Ahsa, Saudi Arabia.
Ejaz AhmadInterdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.
Mir Waqas AlamDepartment of Physics, College of Science, King Faisal University, Al Ahsa, Saudi Arabia.
Md ArshadMolecular Endocrinology Laboratory, Zoology Department, Lucknow University, Lucknow, India.
Mohd Imran AhamedDepartment of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh, India.
King Faisal University · SAAligarh Muslim University · INMajmaah University · SAEra's Lucknow Medical College and Hospital · INUniversity of Lucknow · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although, zinc oxide nanoparticles (ZRTs) as an anti-cancer agent have been the subject of numerous studies, none of the reports has investigated the impact of the reaction entry time of ion-carriers on the preparation of ZRTs. Therefore, we synthesized variants of ZRTs by extending the entry time of NaOH (that acts as a carrier of hydroxyl ions) in the reaction mixture. The anti-proliferative action, morphological changes, reactive oxygen species (ROS) production, and nuclear apoptosis of ZRTs on human A431 skin carcinoma cells were observed. The samples revealed crystallinity and purity by X-ray diffraction (XRD). Scanning electron microscopy (SEM) images of ZRT-1 (5 min ion carrier entry) and ZRT-2 (10 min ion carrier entry) revealed microtubule like morphology. On prolonging the entry time for ion carrier (NaOH) introduction in the reaction mixture, a relative ascent in the aspect ratio was seen. The typical ZnO band with a slight shift in the absorption maxima was evident with UV-visible spectroscopy. Both ZRT-1 and ZRT-2 exhibited non-toxic behavior as evident by RBC lysis assay. Additionally, ZRT-2 showed better anti-cancer potential against A431 cells as seen by MTT assay, ROS generation and chromatin condensation analyses. At 25 μM of ZRT-2, 5.56% cells were viable in MTT test, ROS production was enhanced to 166.71%, while 33.0% of apoptotic cells were observed. The IC

Indexed as

malignant cell linesMTT assayreactive oxygen speciessol-gel synthesiszinc oxide nanoparticles

Identifiers

PMID36531331
PMCPMC9751667
OpenAlexW4311058090

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.