ArticleEFSA journal. European Food Safety Authority2022
The use of NAMs and omics data in risk assessment.
Article in EFSA journal. European Food Safety Authority, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
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- New Challenges in the Monitoring, Risk Assessment, and Management of Pesticides and Biocides in the "One Health Era".Journal of xenobiotics · 2026Article
- Editorial: Application of new approach methodologies in toxicological assessment of next-generation tobacco and nicotine products.Frontiers in toxicology · 2026Article
- Targeting Melanin Production: The Safety of Tyrosinase Inhibition.International journal of molecular sciences · 2025Review
- The OASIS Consortium: integrating multi-omics technologies to transform chemical safety assessment.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- EcoToxChip provides insights into pathway perturbation upon chlorantraniliprole exposure to larval fathead minnow.Aquatic toxicology (Amsterdam, Netherlands) · 2025Article
- Chemical Food Safety in Europe Under the Spotlight: Principles, Regulatory Framework and Roadmap for Future Directions.Foods (Basel, Switzerland) · 2025Review
- Specific effects on liver relevant for performing a dietary cumulative risk assessment of pesticide residues.EFSA journal. European Food Safety Authority · 2025Article
- Advancing human health risk assessment: the role of new approach methodologies.Frontiers in toxicology · 2025Review
- Unlocking the future of environmental safety: a framework for integrating new approach methodologies in decision-making.NAM journal · 2025Article
- Comparative assessment of solvents toxicity using early life stages of amphibians and cell lines: a case study with dimethyl sulfoxide.Frontiers in toxicology · 2025Article
- Simulation of the Long-Term Toxicity Towards Bobwhite Quail (Journal of xenobiotics · 2024Article
- Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines.Archives of toxicology · 2024Article
- Toxicological evaluation of microbial secondary metabolites in the context of European active substance approval for plant protection products.Environmental health : a global access science source · 2024Review
- Toxicometabolomics as a tool for next generation environmental risk assessment.EFSA journal. European Food Safety Authority · 2023Article
- Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report.Mutagenesis · 2023Article
- Metabolites in the regulatory risk assessment of pesticides in the EU.Frontiers in toxicology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The animal-centric approach so far predominantly employed in risk assessment has been questioned in recent years due to a number of shortcomings regarding performance, consistency, transferability of results, sustainability, costs and ethical reasons. Alternatives to animal testing, collectively termed NAMs, may have the potential to deliver sound, cost-effective, prompt and reliable information, but their regulatory acceptance has not been established yet. The main reasons behind this are mostly related to actual methodological obstacles, with particular reference to addressing complex endpoints such as repeated-dose toxicity, the issue of translating the concept of adversity to NAMs, and doubts of stakeholders about the level of chemical safety ensured by NAMs. With the aim of providing an updated view on major conceptual and methodological developments in the field of toxicology, a symposium and a workshop were organised by the German Federal Institute for Risk Assessment (Bundesinstitut für Risikobewertung, BfR) and Helmholtz Centre for Environmental Research on 15-17 November 2021 in Berlin. The conference, entitled 'Challenges in Public Health Protection in the 21st Century: New Methods, Omics and Novel Concepts in Toxicology' brought together eminent scientists with representatives from industry and regulatory authorities. The organisation, day-to-day operations and the reporting of the event main outcomes in a position paper were the main focus of the present EFSA EU-FORA work programme. Tasks pertaining to 'The use of NAMs and omics data in risk assessment' were implemented under the shared supervision of units 'Testing and Assessment Strategies Pesticides' and 'Effect-based Analytics and Toxicogenomics' of the German Federal Institute for Risk Assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.