Polymer modification of SARS-CoV-2 spike protein impacts its ability to bind key receptor.

Monica Sharfin Rahman, Nethmi De Alwis Watuthanthrige, Bhagya M Chandrarathne, Richard C Page, Dominik Konkolewicz

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In one paragraph

Article in European polymer journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Monica Sharfin RahmanDepartment of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, OH 45011, USA.

Nethmi De Alwis WatuthanthrigeDepartment of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, OH 45011, USA.

Bhagya M ChandrarathneDepartment of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, OH 45011, USA.

Richard C PageDepartment of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, OH 45011, USA.

Dominik KonkolewiczDepartment of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, OH 45011, USA.

Miami University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global spread of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) has caused the loss of many human lives and severe economic losses. SARS-CoV-2 mediates its infection in humans via the spike glycoprotein. The receptor binding domain of the SARS-CoV-2 spike protein binds to its cognate receptor, angiotensin converting enzyme-2 (ACE2) to initiate viral entry. In this study, we examine how polymer modification of the spike protein receptor binding domain impacts binding to ACE2. The horseradish peroxidase conjugated receptor binding domain was modified with a range of polymers including hydrophilic

Indexed as

Grafting toProtein-polymer conjugationProtein–protein interactionsRAFTSpike protein

Identifiers

PMID36531158

DOI10.1016/j.eurpolymj.2022.111767

PMCPMC9749382

OpenAlexW4311465686

What OpenQuestion holds

Textmetadata

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.