Evidence map›Paper›PMID 36531044›Full record

ArticleFrontiers in oncology2022

Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy.

Karolina Seborova, Viktor Hlavac, Petr Holy, Sunniva S Bjørklund, Thomas Fleischer, Lukas Rob, Martin Hruda, Jiri Bouda, Marcela Mrhalova, Mohammad Moufaq Khatar Al Obeed Allah and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06680791 (Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle Factors), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06680791 recruitingnot on this mapstarted 2024, after this paper: background citation

Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle Factors

TypeobservationalSponsorLukas VanekRan2024 to 2028Enrolled280ConditionsEndometrial Cancer, Genetic Predisposition, Risk Behavior
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Importance of Germline and Somatic Alterations in HumanInternational journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Karolina SeborovaToxicogenomics Unit, National Institute of Public Health in Prague, Prague, Czechia.
Viktor HlavacToxicogenomics Unit, National Institute of Public Health in Prague, Prague, Czechia.
Petr HolyToxicogenomics Unit, National Institute of Public Health in Prague, Prague, Czechia.
Sunniva S BjørklundDepartment of Medical Genetics, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Thomas FleischerDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Lukas RobDepartment of Gynecology and Obstetrics, Third Faculty of Medicine and University Hospital Kralovske Vinohrady, Prague, Czechia.
Martin HrudaDepartment of Gynecology and Obstetrics, Third Faculty of Medicine and University Hospital Kralovske Vinohrady, Prague, Czechia.
Jiri BoudaDepartment of Gynecology and Obstetrics, University Hospital in Pilsen, Charles University, Pilsen, Czechia.
Marcela MrhalovaDepartment of Pathology and Molecular Medicine, Motol University Hospital, Second Faculty of Medicine, Charles University, Prague, Czechia.
Mohammad Moufaq Khatar Al Obeed AllahBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Pavel VodickaBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Ondrej FialaDepartment of Oncology and Radiotherapeutics, Faculty of Medicine in Pilsen and University Hospital, Charles University, Pilsen, Czechia.
Pavel SoucekToxicogenomics Unit, National Institute of Public Health in Prague, Prague, Czechia.
Vessela N KristensenDepartment of Medical Genetics, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Ludmila VodickovaBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Radka VaclavikovaToxicogenomics Unit, National Institute of Public Health in Prague, Prague, Czechia.
Charles University · CZNational Institute of Public Health · CZUniversity Hospital Kralovske Vinohrady · CZUniversity of Oslo · NOCzech Academy of Sciences, Institute of Experimental Medicine · CZOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial ovarian carcinoma (EOC) is known for high mortality due to diagnosis at advanced stages and frequent therapy resistance. Previous findings suggested that the DNA repair system is involved in the therapeutic response of cancer patients and DNA repair genes are promising targets for novel therapies. This study aimed to address complex inter-relations among gene expression levels, methylation profiles, and somatic mutations in DNA repair genes and EOC prognosis and therapy resistance status. We found significant associations of

Indexed as

biomarkersDNA repair genesmethylomeovarian carcinomaresistancetranscriptometreatment responsewhole exome sequencing

Identifiers

PMID36531044
PMCPMC9755737
OpenAlexW4311105719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.