Evidence map›Paper›PMID 36530969›Full record

ArticleFrontiers in oncology2022

Durable complete response for oligometastatic renal cell carcinoma with immune checkpoint inhibition and cytoreductive nephrectomy in a Jehovah's witness: A case report.

Tony Zibo Zhuang, Lara Harik, Seth Force, Agreen Hadadi, Mehmet Asim Bilen, Jacqueline T Brown, Bradley C Carthon, Jamie Goldman, Omer Kucuk, Viraj A Master and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Tony Zibo ZhuangSchool of Medicine, Emory University, Atlanta, GA, United States.
Lara HarikDepartment of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA, United States.
Seth ForceWinship Cancer Institute of Emory University, Atlanta, GA, United States.
Agreen HadadiSchool of Medicine, Emory University, Atlanta, GA, United States.
Mehmet Asim BilenWinship Cancer Institute of Emory University, Atlanta, GA, United States.
Jacqueline T BrownWinship Cancer Institute of Emory University, Atlanta, GA, United States.
Bradley C CarthonWinship Cancer Institute of Emory University, Atlanta, GA, United States.
Jamie GoldmanWinship Cancer Institute of Emory University, Atlanta, GA, United States.
Omer KucukWinship Cancer Institute of Emory University, Atlanta, GA, United States.
Viraj A MasterWinship Cancer Institute of Emory University, Atlanta, GA, United States.
Bassel NazhaWinship Cancer Institute of Emory University, Atlanta, GA, United States.
Emory University · USEmory University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of cytoreductive nephrectomy in patients with metastatic renal cell carcinoma is a subject of debate. We report a durable complete response in a 62-year-old man Jehovah's Witness with metastatic clear cell renal cell carcinoma who received two cycles of nivolumab/ipilimumab followed by radical nephrectomy and metastasectomy of known pulmonary disease site, both without a clinical need for perioperative blood transfusions. The patient continues to be without evidence of disease and without additional need for systemic therapy over a year after his radical nephrectomy. The case highlights that cytoreductive nephrectomy continues to play a role in the era of immune checkpoint inhibitors.

Indexed as

cytoreductiveipilimumabnivolumaboligometastaticrenal cell carcinomaTKI (tyrosine kinase inhibitor)

Identifiers

PMID36530969
PMCPMC9755666
OpenAlexW4310611345

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.