Evidence map›Paper›PMID 36530585›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2022

Association Between Serum Vitamin D Levels and Ketosis Episodes in Hospitalized Patients with Newly Diagnosed Ketosis-Prone Type 2 Diabetes.

Xiaoyu He, Yu Luo, Jianan Hao, Cuiyu Wang, Kexin Gan, Yunfeng Zhen, Luping Ren

Open access · goldAbstract read
In one paragraph

Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. The Role of Vitamin D in Diabetes Ketosis and Ketoacidosis.Chronic diseases and translational medicine · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xiaoyu HeEndocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.ORCID 0000-0002-1274-8169
Yu LuoEndocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
Jianan HaoEndocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.ORCID 0000-0003-1869-9633
Cuiyu WangEndocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.ORCID 0000-0002-4734-1924
Kexin GanEndocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
Yunfeng ZhenEndocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
Luping RenEndocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
Hebei General Hospital · CNHebei Medical University · CNNorth China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to investigate the relationship between 25-hydroxyvitamin D (25OHD) and the onset of ketosis in newly diagnosed patients with ketosis-prone type 2 diabetes (KPT2D). Patients and Methods: A total of 162 patients with non-autoimmune newly diagnosed diabetes mellitus were included in this cross-sectional study. Patients were classified into KPT2D (n = 71) or non-ketotic type 2 diabetes (NKT2D, n = 91). Anthropometric parameters, islet functions, biochemical parameters, and body composition were determined in both KPT2D and NKT2D groups. Correlation analysis was performed to determine the associations between 25OHD and plasma ketones. The risk factors associated with ketosis episodes in patients with new-onset KPT2D were evaluated using binary logistic regression analysis. Results: Vitamin D deficiency was observed in both patients with KPT2D and NKT2D. Compared with the NKT2D group, serum 25OHD values were lower in the participants of the KPT2D group [14.20 (10.68, 19.52) vs 16.98 (13.54,2.96) ng/mL, P = 0.011]. Serum 25OHD was associated with plasma ketones (R = -0.387). Serum 25OHD is an independent protective factor for ketosis or ketoacidosis episodes in patients with new onset of KPT2D (P = 0.037, OR = 0.921). Conclusion: Vitamin D levels are associated with ketosis episodes in patients with KPT2D. Serum 25OHD is an independent protective factor for ketosis episodes in patients with KPT2D.

Indexed as

diabetic ketosisketosis-onsetnewly onset ketosis-prone diabetesvitamin D

Identifiers

PMID36530585
PMCPMC9757126
OpenAlexW4311407099

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.