ReviewTheScientificWorldJournal2022
An Overview of Hormone-Sensitive Lipase (HSL).
Review in TheScientificWorldJournal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation-a systematic review.Naunyn-Schmiedeberg's archives of pharmacology · 2024Pooled it
- Bridging Glycemic and Lipid Control: Effects of Dapagliflozin in Co-Morbid Diabetes and Heart Failure – A Randomized Controlled TrialEndocrine, metabolic & immune disorders drug targets · 2026Trial
- Effects of SIRT7 Inhibition on Milk Fat Synthesis and Fatty Acid Composition in Dairy Goat Mammary Epithelial Cells.Animals : an open access journal from MDPI · 2026Article
- Baicalin Modulates Hepatic Lipid Metabolism and Improves Intestinal Health in White-Feathered Broilers.Biology · 2026Article
- Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk.Current obesity reports · 2026Review
- Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk.Immunity, inflammation and disease · 2026Review
- Effects of Maternal Pterostilbene Supplementation on Milk Composition and Offspring Gut Antioxidant/Lipid Metabolism in Suckling Piglets: A Multi-Omics Study.Antioxidants (Basel, Switzerland) · 2026Article
- Lipid droplets in neurodegenerative diseases: pathological drivers and therapeutic vulnerabilities.Cell death discovery · 2026Review
- Canagliflozin regulates adipocyte lipolysis in vitro via a SGLT2 independent signaling pathway.International journal of obesity (2005) · 2026Article
- Dietary glucuronolactone alleviates hepatic lipid accumulation via the enterohepatic axis in laying hens.Journal of animal science and biotechnology · 2026Article
- Anti-Obesity Activity of GiantInternational journal of molecular sciences · 2026Article
- Gut Microbiome Signatures of Aging Associated with Intramuscular Fat Deposition in Tan Sheep.Animals : an open access journal from MDPI · 2026Article
- Acteoside prevents high-fat diet-induced obesity by regulating brown adipose tissue production, lipid metabolism, and the gut microbiota.European journal of medical research · 2026Article
- Dietary Supplementation With Olive Leaf Extract Alleviated Lipid Accumulation and Improved Growth and Intestinal Flora inAquaculture nutrition · 2026Article
- RNA sequencing reveals lncRNAs that specifically regulate unsaturated fatty acid generation in buffaloes.Archives animal breeding · 2026Article
- Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications.Frontiers in pharmacology · 2026Review
- Acetamiprid exerts sex-specific effects on adipose tissue of subjects with severe obesity.Frontiers in toxicology · 2026Article
- Chinese Yam Polysaccharide Ameliorates Obesity by Promoting Lipolysis Via the cAMP/PKA Signaling Pathway.Chemistry & biodiversity · 2026Article
- Reduced Pseudocholinesterase Levels Are Associated With Alterations in Lipid Biomarkers and Liver Enzymes Among Ghanaian Male Cocoa Farmers Using Organophosphate Pesticides.TheScientificWorldJournal · 2026Article
- The Importance of Serum Perilipin-2 Level as an Early Indicator of Inflammation in Non-Alcoholic Fatty Liver Disease.Diagnostics (Basel, Switzerland) · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormone-sensitive lipase (HSL) is a pivotal enzyme that mediates triglyceride hydrolysis to provide free fatty acids and glycerol in adipocytes in a hormonally controlled lipolysis process. Elevated plasma-free fatty acids were accompanied by insulin resistance, type-2 diabetes, and obesity. Inhibition of lipolysis through HSL inhibition may provide a mechanism to prevent the accumulation of free fatty acids and to improve the affectability of insulin and blood glucose handling in type II diabetes. The published studies that examine the structure, regulation, and function of HSL and major inhibitors were reviewed in this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.