Evidence map›Paper›PMID 36530422›Full record

ArticleFrontiers in cellular and infection microbiology2022

Targeting malaria parasites with novel derivatives of azithromycin.

Amy L Burns, Brad E Sleebs, Maria Gancheva, Kimberley T McLean, Ghizal Siddiqui, Henrietta Venter, James G Beeson, Ryan O'Handley, Darren J Creek, Shutao Ma and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Vesicular mechanisms of drug resistance in apicomplexan parasites.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Amy L BurnsResearch Centre for Infectious Diseases, School of Biological Sciences, the University of Adelaide, Adelaide, SA, Australia.
Brad E SleebsACRF Chemical Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Maria GanchevaResearch Centre for Infectious Diseases, School of Biological Sciences, the University of Adelaide, Adelaide, SA, Australia.
Kimberley T McLeanResearch Centre for Infectious Diseases, School of Biological Sciences, the University of Adelaide, Adelaide, SA, Australia.
Ghizal SiddiquiDrug Delivery Disposition and Dynamics, Monash University, Parkville, VIC, Australia.
Henrietta VenterHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
James G BeesonHealthy Mothers, Healthy Babies Program, Burnet Institute, Melbourne, VIC, Australia.
Ryan O'HandleySchool of Animal and Veterinary Science, University of Adelaide, Adelaide, SA, Australia.
Darren J CreekDrug Delivery Disposition and Dynamics, Monash University, Parkville, VIC, Australia.
Shutao MaDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Sonja FrölichResearch Centre for Infectious Diseases, School of Biological Sciences, the University of Adelaide, Adelaide, SA, Australia.
Christopher D GoodmanSchool of BioSciences, University of Melbourne, Parkville, VIC, Australia.
Geoffrey I McFaddenSchool of BioSciences, University of Melbourne, Parkville, VIC, Australia.
Danny W WilsonResearch Centre for Infectious Diseases, School of Biological Sciences, the University of Adelaide, Adelaide, SA, Australia.
University of Adelaide · AUMonash University · AUUniversity of Melbourne · AUShandong University · CNUniversity of New England · AUUniversity of South Australia · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
NIDDK NIH HHS U2C DK119886
6 · The paper itself

Abstract

Introduction: The spread of artemisinin resistant Methods: Here, 22 azithromycin analogues were explored for delayed death and quick-killing activities against Results: Seventeen analogues showed improved quick-killing against both Discussion: The azithromycin analogues characterised in this study expand the structural diversity over previously reported quick-killing compounds and provide new starting points to develop azithromycin analogues with quick-killing antimalarial activity.

Indexed as

AntimalarialsMalariaMalaria, FalciparumParasitesAnimalsAzithromycinChloroquineHumansPlasmodium falciparumAntimalarialsAzithromycinChloroquineantimalarialazithromycinmalariaPlasmodiumquick-killing

Identifiers

PMID36530422
PMCPMC9748569
OpenAlexW4311040537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.