SynthesisFrontiers in human neuroscience2022
Association between loneliness and dementia risk: A systematic review and meta-analysis of cohort studies.
Synthesis in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Loneliness as an Interface Between Alzheimer's Disease and Suicidal Behaviour: A Systematic Review, Meta-Analysis and Meta-Analytic Factor Analysis.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Pooled it
- Non-Genetic Risk Factors of Alzheimer's Disease: An Updated Umbrella Review.The journal of prevention of Alzheimer's disease · 2024Pooled it
- Meditation training and non-native language training both reduce older adults loneliness in the age-well randomized controlled trial.Scientific reports · 2025Trial
- Cross-sectional associations of loneliness with plasma p-tau217 and neurofilament light chain in dementia-free older adults in the INSPIRE-T baseline cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Is my loneliness killing me? Effects of loneliness and social isolation on transitions between cognitive status categories and death.Journal of personality and social psychology · 2026Article
- Racial/ethnic variation of neighborhood social cohesion, loneliness, and cognitive functioning among midlife and older U.S. adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.Nature communications · 2026Article
- The Longitudinal Impact of Psychosocial Factors on Cognition and Hearing in Younger and Older Adults During the COVID-19 Pandemic.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Physical activity and loneliness interrelations with retirement status, health, and personality factors: a theory-based study.Frontiers in psychology · 2026Article
- Association between chronic gastrointestinal diseases and frailty: unveiling the mediating effect of loneliness.BMC public health · 2025Article
- Factors associated with mild cognitive impairment and dementia amongst the oldest old: findings based on the nationally representative "old age in Germany (D80+)" study.Aging clinical and experimental research · 2025Article
- Prevalence of loneliness and social isolation among individuals with mild cognitive impairment or dementia: systematic review and meta-analysis.BJPsych open · 2025Review
- Psychosocial burdens in early- versus late-onset dementia: analysis of discrimination, stress, and loneliness in the All of Us Research Program.Innovation in aging · 2025Article
- A Meta-analysis of Loneliness and Risk of Dementia using Longitudinal Data from >600,000 Individuals.Nature. Mental health · 2024Article
- Loneliness, cerebrovascular and Alzheimer's disease pathology, and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cross-sectional association of food insecurity with loneliness in older adults: The role of sex, age, and psychosomatic factors.The journal of nutrition, health & aging · 2024Article
- COVID-19 restrictions promoted the newly occurring loneliness in older people - a prospective study in a memory clinic population.Frontiers in psychiatry · 2024Article
- Loneliness Among Older Adults Receiving Long-Term Home Care Services: A Quantitative Study.SAGE open nursingArticle
- Fear of Dementia among Middle-Aged and Older Adults in Germany.Dementia and geriatric cognitive disorders extraArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loneliness has been reported to be associated with an increased risk of dementia; however, the extent of this relationship remains controversial. This study aimed to assess the strength of the relationship between loneliness and dementia using a meta-analysis approach. PubMed, EMBASE, and China National Knowledge Internet databases were systematically searched for potentially included studies from inception up to 17 February 2022. A meta-analysis was performed using a random-effects model to assess pooled relative risks (RRs) and 95% confidence intervals (CIs). A literature search identified 16 cohort studies (published in 15 articles), among which 4,625 dementia cases and 62,345 individuals were selected for further meta-analysis. Loneliness was associated with an increased risk of Alzheimer's disease (AD) (RR: 1.72, 95% CI: 1.32-2.23;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.