Evidence map›Paper›PMID 36529794›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Association between fibrinogen-to-albumin ratio and hemorrhagic transformation after intravenous thrombolysis in ischemic stroke patients.

Miaomiao Yang, Lisha Tang, Shijia Bing, Xiangqi Tang

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

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8citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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8 citing papers in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Miaomiao YangDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lisha TangDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shijia BingDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiangqi TangDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. txq6633@csu.edu.cn.ORCID http://orcid.org/0000-0003-1709-4456

Funding

Natural Science Foundation of Hunan Province 2022JJ30841
6 · The paper itself

Abstract

background and purposeHemorrhagic transformation (HT) is the most serious complication of intravenous thrombolysis in ischemic stroke patients. Inflammation plays a critical role in the pathological progression of HT. This study was to explore the relationship between fibrinogen-to-albumin ratio (FAR), a novel systemic inflammation biomarker, and HT after intravenous thrombolysis in patients with ischemic stroke.

methodsThis retrospective study enrolled ischemic stroke patients who underwent intravenous thrombolysis between Jan 2017 to May 2022. The characteristic data of all patients at admission were retrospectively collected. The univariate and multivariate logistic regression analyses were performed to evaluate the correlation between FAR and HT after intravenous thrombolysis. The optimal cut-off value of FAR for predicting HT was determined by the receiver operating characteristic curve.

resultsA total of 363 ischemic stroke patients were enrolled in the present study. Sixty-two patients had HT after intravenous thrombolysis. In multivariate regression analysis, FAR was significantly associated with HT (odds ratio [OR], 1.105; 95% confidential interval [CI], 1.029-1.186, P = 0.006). The receiver operating characteristic curve analysis indicated FAR predicts HT after intravenous thrombolysis with an AUC of 0.613 (95%CI, 0.530-0.695; P = 0.005) and an optimal cut-off value of 0.101. The correlation between FAR and HT after intravenous thrombolysis was still observed when patients were stratified according to FAR levels. A higher FAR level was independently related to the occurrence of HT after adjusting for the potential confounding factors.

conclusionHigher FAR level was independently associated with HT after intravenous thrombolysis in patients with ischemic stroke.

Indexed as

Brain IschemiaIschemic StrokeStrokeAlbuminsFibrinogenHumansInflammationRetrospective StudiesThrombolytic TherapyTissue Plasminogen ActivatorAlbuminsFibrinogenTissue Plasminogen ActivatorFibrinogen-to-albumin ratioHemorrhagic transformationIntravenous thrombolysisIschemic strokeNeuroinflammation

Identifiers

PMID36529794

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.