Evidence map›Paper›PMID 36529793›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Probiotic supplementation improved cognitive function in cognitively impaired and healthy older adults: a systematic review of recent trials.

Yvonne Suzy Handajani, Antoninus Hengky, Elisabeth Schröder-Butterfill, Eef Hogervorst, Yuda Turana

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yvonne Suzy HandajaniSchool of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya, No. 2, Jakarta, 14440, Indonesia. yvonne.hand@atmajaya.ac.id.ORCID http://orcid.org/0000-0002-8245-9354
Antoninus HengkyCenter of Health Research, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Elisabeth Schröder-ButterfillUniversity of Southampton, Southampton, UK.
Eef HogervorstSport Exercise & Health Sciences, Loughborough University, Loughborough, UK.
Yuda TuranaSchool of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya, No. 2, Jakarta, 14440, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRecent evidence suggests that there is clear association between microbiota and cognitive functioning, which is known as microbiome-gut-brain axis. Probiotic bacteria consumption can alter human microbiota; therefore, probiotic supplementation might affect the gut microbiota dynamics and influence cognitive function.

methodsThree electronic databases including PubMed, ProQuest, and EBSCOHost databases were utilized. Manual hand search of article was also done. We selected randomized controlled trial articles that measure cognitive function (as the primary outcome) after intervention with probiotic supplementation on older adult population with AD, MCI, or healthy condition. The following terms and its variant were used: "probiotic," "cognitive function," "mild cognitive impairment," "dementia," and "Alzheimer's disease."

resultNine of 10 included studies (AD, MCI, or healthy cognition population) showed cognitive function was improved significantly after probiotic supplementation, compared to control group. One study that included severe AD did not show significant changes.

conclusionMost studies involving AD, MCI, or healthy older adults showed cognitive improvement in subjects treated with probiotics for 12-24 weeks.

Indexed as

Alzheimer DiseaseCognition DisordersCognitive DysfunctionProbioticsAgedCognitionHumansCognitive functionCognitive impairmentDementiaOlder adultsProbiotic

Identifiers

PMID36529793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.