SynthesisActa neurochirurgica2023
Antibiotic prophylaxis in penetrating traumatic brain injury: analysis of a single-center series and systematic review of the literature.
Synthesis in Acta neurochirurgica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Effectiveness of prophylactic antibiotics for the prevention of intracranial infections following penetrating traumatic brain injury: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Guideline
- Article
- Civilian penetrating traumatic brain injury in South-East Norway.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- From Neurological Severity to Anatomical Burden: An Integrated Clinical-CT Model for Predicting In-Hospital Mortality in Adults with Penetrating Cranial Gunshot Injuries.Diagnostics (Basel, Switzerland) · 2026Article
- Penetrating brain injury with a nail gun: technical considerations and the role of cerebral angiography. Illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A lateral suboccipital approach for hemostasis in removing transorbital, transcavernous penetrating chopsticks: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Article
- Therapeutic Drug Distribution across the Mouse Brain Is Heterogeneous as Revealed by In Vivo, Spatially Resolved Aptamer-Based Sensing.ACS pharmacology & translational science · 2025Article
- The Approach to Cranioorbital Gunshot Wounds.Seminars in plastic surgery · 2025Review
- Endoscopic endonasal drainage of a foreign body-associated brain abscess.Surgical neurology international · 2025Article
- Case Report: an unusual case of a penetrating intracranial metallic foreign body removed via surgery.Frontiers in surgery · 2025Article
- Primary reconstruction of depressed frontal bone fracture including cranialization of frontal sinus and repair of forehead skin: a case report and literature review.AME case reports · 2025Article
- Delayed cerebellar abscess developed 38 years after craniocerebral gunshot wound: A case report.Surgical neurology international · 2025Article
- The Current Update of Conventional and Innovative Treatment Strategies for Central Nervous System Injury.Biomedicines · 2024Review
- Endoscopic Endonasal Removal of a Bullet Lodged in the Anterior Lower Clivus: A Case Report.Korean journal of neurotrauma · 2024Article
- Article
- Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models.BMC neuroscience · 2024Review
- How I do it: single-staged emergency neurosurgical management of frontal penetrating craniocerebral injury with depressed skull fracture.Acta neurochirurgica · 2024Article
- Transmastoid pediatric penetrating brain injury, interdisciplinary, and tailored patient's treatment.Surgical neurology international · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposePenetrating traumatic brain injury (pTBI) is an acute medical emergency with a high rate of mortality. Patients with survivable injuries face a risk of infection stemming from foreign body transgression into the central nervous system (CNS). There is controversy regarding the utility of antimicrobial prophylaxis in managing such patients, and if so, which antimicrobial agent(s) to use.
methodsWe reviewed patients with pTBI at our institution and performed a PRISMA systematic review to assess the impact of prophylactic antibiotics on reducing risk of CNS infection.
resultsWe identified 21 local patients and 327 cases in the literature. In our local series, 17 local patients received prophylactic antibiotics; four did not. Overall, five of these patients (24%) developed a CNS infection (four and one case of intraparenchymal brain abscess and meningitis, respectively). All four patients who did not receive prophylactic antibiotics developed an infection (three with CNS infections; one superficial wound infection) compared to two of 17 (12%) patients who did receive prophylactic antibiotics. Of the 327 pTBI cases reported in the literature, 216 (66%) received prophylactic antibiotics. Thirty-eight (17%) patients who received antibiotics developed a CNS infection compared to 21 (19%) who did not receive antibiotics (p = 0.76).
conclusionsAlthough our review of the literature did not reveal any benefit, our institutional series suggested that patients with pTBI may benefit from prophylactic antibiotics. We propose a short antibiotic course with a regimen specific to cases with and without the presence of organic debris.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.