Evidence map›Paper›PMID 36529781›Full record

Trial reportJournal of cardiothoracic surgery2022

Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction.

Maina P Jalava, Mikko Savontaus, Tuomas Ahvenvaara, Teemu Laakso, Marko Virtanen, Matti Niemelä, Tuomas Tauriainen, Pasi Maaranen, Annastiina Husso, Eve Kinnunen and 13 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cardiothoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03385915 (Nationwide Finnish Registry of Transcatheter and Surgical Aortic Valve Replacement for Aortic Valve Stenosis), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03385915 completednot on this map

Nationwide Finnish Registry of Transcatheter and Surgical Aortic Valve Replacement for Aortic Valve Stenosis: FinnValve Registry

TypeobservationalSponsorTurku University HospitalRan2017 to 2020Enrolled6,463ConditionsAortic Valve StenosisArmsAortic valve replacement
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 2 countries.

Maina P JalavaHeart Centre, Turku University Hospital and University of Turku, P. O. Box 52, 20521, Turku, Finland. maina.jalava@tyks.fi.
Mikko SavontausHeart Centre, Turku University Hospital and University of Turku, P. O. Box 52, 20521, Turku, Finland.
Tuomas AhvenvaaraDepartment of Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland.
Teemu LaaksoHeart Center, Helsinki University Hospital, Helsinki, Finland.
Marko VirtanenHeart Hospital, Tampere University Hospital and University of Tampere, Tampere, Finland.
Matti NiemeläDepartment of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Tuomas TauriainenDepartment of Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland.
Pasi MaaranenHeart Hospital, Tampere University Hospital and University of Tampere, Tampere, Finland.
Annastiina HussoHeart Center, Kuopio University Hospital, Kuopio, Finland.
Eve KinnunenHeart Center, Helsinki University Hospital, Helsinki, Finland.
Sebastian DahlbackaHeart Center, Helsinki University Hospital, Helsinki, Finland.
Jussi JaakkolaHeart Centre, Turku University Hospital and University of Turku, P. O. Box 52, 20521, Turku, Finland.
Stefano RosatoNational Centre of Global Health, Istituto Superiore di Sanità, Rome, Italy.
Paola D'ErrigoNational Centre of Global Health, Istituto Superiore di Sanità, Rome, Italy.
Mika LaineHeart Center, Helsinki University Hospital, Helsinki, Finland.
Timo MäkikallioDepartment of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Peter RaivioHeart Center, Helsinki University Hospital, Helsinki, Finland.
Markku EskolaHeart Hospital, Tampere University Hospital and University of Tampere, Tampere, Finland.
Antti ValtolaHeart Center, Kuopio University Hospital, Kuopio, Finland.
Tatu JuvonenDepartment of Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland.
Fausto BiancariClinica Montevergine, GVM Care and Research, Mercogliano, Italy.
Juhani AiraksinenHeart Centre, Turku University Hospital and University of Turku, P. O. Box 52, 20521, Turku, Finland.
Vesa AnttilaHeart Centre, Turku University Hospital and University of Turku, P. O. Box 52, 20521, Turku, Finland.
Helsinki University Hospital · FITurku University Hospital · FITampere University · FIIstituto Superiore di Sanità · ITKuopio University Hospital · FIOulu University Hospital · FIUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis.

methodsThe retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction.

resultsWithin the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067-1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929-1.080, p = 0.964), respectively.

conclusionsReduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915.

Indexed as

Aortic Valve StenosisHeart Valve Prosthesis ImplantationTranscatheter Aortic Valve ReplacementVentricular Dysfunction, LeftAortic ValveHumansRetrospective StudiesRisk FactorsStroke VolumeTreatment OutcomeVentricular Function, LeftAortic stenosis, ASHeart failureLeft ventricular dysfunctionLeft ventricular ejection fractionSurgical aortic valve replacement, SAVRTranscatheter aortic valve replacement, TAVR

Identifiers

PMID36529781
PMCPMC9759878
OpenAlexW4311835453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.