Observational studyRespiratory research2022
Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study.
Observational study in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Characteristics of scores used for quantitative lung ultrasound in neonates: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Diagnostic accuracy of lung ultrasound to predict weaning outcome: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Comparison of different types of ultrasound probes for lung ultrasound in neonates-A prospective randomized comparison study.PloS one · 2024Trial
- Lung ultrasound-guided best positive end-expiratory pressure in neonatal anesthesia: a proposed randomized, controlled study.Pediatric research · 2024Trial
- PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome.Intensive care medicine · 2026Review
- Lung ultrasound-guided positioning strategy for the prevention of ventilator-associated pneumonia in neonates.Frontiers in pediatrics · 2026Article
- Bedside thoracic echography in ICU: new insights for acute circulatory and respiratory failure.Intensive care medicine · 2026Review
- Imaging and pulmonary function techniques in ARDS diagnosis and management: current insights and challenges.Critical care (London, England) · 2025Review
- The Use of Lung Ultrasound Rather than Chest X-Ray to Diagnose Neonatal Lung Disease: Time for Action.Diagnostics (Basel, Switzerland) · 2025Article
- ESICM-ESPNIC international expert consensus on quantitative lung ultrasound in intensive care.Intensive care medicine · 2025Article
- Lung Ultrasound After COVID-19: A Pivotal Moment for Clinical Integration-Navigating Challenges and Seizing Opportunities.Healthcare (Basel, Switzerland) · 2025Review
- Relationship between lung consolidation size measured by ultrasound and outcome in ICU patients with respiratory failure.BMC pulmonary medicine · 2025Observational
- Correlation of sonographic and radiographic scores of lung edema and metrics of shunt, dead space, and respiratory mechanics in invasively ventilated patients.Critical care science · 2025Observational
- Effect of different CPAP levels on ultrasound-assessed lung aeration and gas exchange in neonates.Respiratory research · 2024Observational
- A versatile role for lung ultrasound in systemic autoimmune rheumatic diseases related pulmonary involvement: a narrative review.Arthritis research & therapy · 2024Review
- Thoracic fluid content (TFC) using electrical cardiometry versus lung ultrasound in the diagnosis of transient tachypnea of newborn.European journal of pediatrics · 2024Observational
- A study of machine learning to predict NRDS severity based on lung ultrasound score and clinical indicators.Frontiers in medicine · 2024Article
- The value of lung ultrasound score in neonatal respiratory distress syndrome: a prospective diagnostic cohort study.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung ultrasound allows lung aeration to be assessed through dedicated lung ultrasound scores (LUS). Despite LUS have been validated using several techniques, scanty data exist about the relationships between LUS and compliance of the respiratory system (Crs) in restrictive respiratory failure. Aim of this study was to investigate the relationship between LUS and Crs in neonates and adults affected by acute hypoxemic restrictive respiratory failure, as well as the effect of patients' age on this relationship.
methodsObservational, cross-sectional, international, patho-physiology, bi-center study recruiting invasively ventilated, adults and neonates with acute respiratory distress syndrome (ARDS), neonatal ARDS (NARDS) or respiratory distress syndrome (RDS) due to primary surfactant deficiency. Subjects without lung disease (NLD) and ventilated for extra-pulmonary conditions were recruited as controls. LUS, Crs and resistances (Rrs) of the respiratory system were measured within 1 h from each other.
resultsForty adults and fifty-six neonates were recruited. LUS was higher in ARDS, NARDS and RDS and lower in control subjects (overall p < 0.001), while Crs was lower in ARDS, NARDS and RDS and higher in control subjects (overall p < 0.001), without differences between adults and neonates. LUS and Crs were correlated in adults [r = - 0.86 (95% CI - 0.93; - 0.76), p < 0.001] and neonates [r = - 0.76 (95% CI - 0.85; - 0.62), p < 0.001]. Correlations remained significant among subgroups with different causes of respiratory failure; LUS and Rrs were not correlated. Multivariate analyses confirmed the association between LUS and Crs both in adults [B = - 2.8 (95% CI - 4.9; - 0.6), p = 0.012] and neonates [B = - 0.045 (95% CI - 0.07; - 0.02), p = 0.001].
conclusionsLung aeration and compliance of the respiratory system are significantly and inversely correlated irrespective of patients' age. A restrictive respiratory failure has the same ultrasound appearance and mechanical characteristics in adults and neonates.
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