Evidence map›Paper›PMID 36529684›Full record

ArticleInternational journal of STD & AIDS2023

Relationship between raltegravir trough plasma concentration and virologic response and the impact of therapeutic drug monitoring during pregnancy.

Sabrina Carvalho, Nancy L Sheehan, Silvie Valois, Fatima Kakkar, Marc Boucher, Ema Ferreira, Isabelle Boucoiran

Open access · hybridAbstract read
In one paragraph

Article in International journal of STD & AIDS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sabrina CarvalhoFaculty of Pharmacy, Ringgold: 63677Université de Montréal, Montréal, QC, Canada.ORCID 0000-0001-7645-0292
Nancy L SheehanFaculty of Pharmacy, Ringgold: 63677Université de Montréal, Montréal, QC, Canada.
Silvie ValoisMother and Children's Infectious Diseases Center, Ringgold: 70443Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada.
Fatima KakkarMother and Children's Infectious Diseases Center, Ringgold: 70443Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada.
Marc BoucherMother and Children's Infectious Diseases Center, Ringgold: 70443Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada.
Ema FerreiraFaculty of Pharmacy, Ringgold: 63677Université de Montréal, Montréal, QC, Canada.
Isabelle BoucoiranMother and Children's Infectious Diseases Center, Ringgold: 70443Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada.ORCID 0000-0001-9545-6024
Centre Hospitalier Universitaire Sainte-Justine · CAMcGill University Health Centre · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundLimited data is available on raltegravir (RAL) pharmacokinetics during pregnancy and the value of therapeutic drug monitoring (TDM) in pregnancy is unknown. This study aims to describe RAL trough plasma concentrations (C

methodsWomen from the prospective mother-infant HIV cohort of Mother and Children's Infectious Diseases Center who received RAL during their pregnancy between 2011-2020 were included. TDM reports were reviewed and C

resultsWe included 76 pregnant women of which 47 underwent TDM. We observed a significant association between virological response and C

conclusionsAn association between RAL C

Indexed as

Anti-HIV AgentsHIV InfectionsPregnancy Complications, InfectiousChildDrug MonitoringFemaleHumansInfant, NewbornPregnancyProspective StudiesRaltegravir PotassiumViral LoadAnti-HIV AgentsRaltegravir PotassiumHIVpregnancyRaltegravirtherapeutic drug monitoring

Identifiers

PMID36529684
PMCPMC9925909
OpenAlexW4311934160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.