Evidence map›Paper›PMID 36529369›Full record

ArticleJournal of sport and health science2023

The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children: The ActiveBrains project.

María Rodriguez-Ayllon, Abel Plaza-Florido, Andrea Mendez-Gutierrez, Signe Altmäe, Patricio Solis-Urra, Concepción M Aguilera, Andrés Catena, Francisco B Ortega, Irene Esteban-Cornejo

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Article in Journal of sport and health science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

María Rodriguez-AyllonPROFITH "PROmoting FITness and Health through physical activity" research group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada 18071, Spain; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3015 GD, the Netherlands.
Abel Plaza-FloridoPROFITH "PROmoting FITness and Health through physical activity" research group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada 18071, Spain.
Andrea Mendez-GutierrezDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada 18071, Spain.
Signe AltmäeDepartment of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada 18071, Spain.
Patricio Solis-UrraPROFITH "PROmoting FITness and Health through physical activity" research group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada 18071, Spain; Nuclear Medicine Services, Virgen de Las Nieves University Hospital, Granada 18014, Spain; Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar 2531015, Chile.
Concepción M AguileraDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada 18071, Spain.
Andrés CatenaDepartment of Experimental Psychology, School of Psychology, University of Granada, Granada 18011, Spain.
Francisco B OrtegaPROFITH "PROmoting FITness and Health through physical activity" research group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada 18071, Spain; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä 40014, Finland; Department of Bioscience and Nutrition, Karolinska Institutet, Huddinge, SE 141 57, Sweden. Electronic address: ortegaf@ugr.es.
Irene Esteban-CornejoPROFITH "PROmoting FITness and Health through physical activity" research group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada 18071, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging research supports the idea that exercise positively affects neurodevelopment. However, the mechanisms linking exercise with brain health are largely unknown. We aimed to investigate the effect of exercise on (a) blood biomarkers selected based on previous evidence (brain-derived neurotrophic factor, β-hydroxybutyrate (BHB), cathepsin B (CTSB), kynurenine, fibroblast growth factor 21 (FGF21), soluble vascular cell adhesion molecule-1 (sVCAM-1)); and (b) a panel of 92 neurology-related proteins (discovery analysis). We also investigated whether changes in these biomarkers mediate the effects of exercise on brain health (hippocampal structure and function, cognitive performance, and mental health).

methodsWe randomized 81 overweight/obese children (10.1 ± 1.1 years, 41% girls) into 2 groups: either 20 weeks of aerobic plus resistance exercise or control. Candidate biomarkers were assessed using enzyme-linked immunosorbent assay (ELISA) for kynurenine, FGF21, and CTSB; colorimetry for β-hydroxybutyrate; and XMap for brain-derived neurotrophic factor and soluble vascular cell adhesion molecule-1. The 92 neurology-related proteins were analyzed by an antibody-based proteomic analysis.

resultsOur intervention had no significant effect on candidate biomarkers (all p > 0.05). In the discovery analysis, a reduction in circulating macrophage scavenger receptor type-I was observed (standardized differences between groups = -0.3, p = 0.001). This effect was validated using ELISA methods (standardized difference = -0.3, p = 0.01). None of the biomarkers mediated the effects of exercise on brain health.

conclusionsOur study does not support a chronic effect of exercise on candidate biomarkers. We observed that while chronic exercise reduced the levels of macrophage scavenger receptor type-I, it did not mediate the effects of exercise on brain health. Future studies should explore the implications of this novel biomarker for overall health.

Indexed as

OverweightPediatric Obesity3-Hydroxybutyric AcidBiomarkersBrainBrain-Derived Neurotrophic FactorChildExercise TherapyFemaleHumansKynurenineMaleProteomicsVascular Cell Adhesion Molecule-13-Hydroxybutyric AcidBiomarkersBrain-Derived Neurotrophic FactorKynurenineVascular Cell Adhesion Molecule-1Brain developmentChildhoodMRIPhysical activityProteomic

Identifiers

PMID36529369
PMCPMC10105026

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.