Evidence map›Paper›PMID 36529309›Full record

ArticleDevelopmental and comparative immunology2023

Environmental endocrine disruptors and amphibian immunity: A bridge between the thyroid hormone axis and T cell development.

Connor C McGuire, Jacques R Robert

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental and comparative immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Connor C McGuireUniversity of Rochester Department of Microbiology and Immunology, USA; University of Rochester Department Environmental Medicine, USA.
Jacques R RobertUniversity of Rochester Department of Microbiology and Immunology, USA; University of Rochester Department Environmental Medicine, USA. Electronic address: Jacques_Robert@urmc.rochester.edu.
University of Rochester · USUniversity of Rochester Medical Center · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Training in Environment ToxicologyT32ES007026 · NIEHS · UNIVERSITY OF ROCHESTER · PI Alison Elder, Marissa Sobolewski Terry · 1985 to 2026
$20.2M
A Xenopus Laevis Research Resource for ImmunologyR24AI059830 · NIAID · UNIVERSITY OF ROCHESTER · PI JACQUES Robert · 2004 to 2026
$7.7M
A Xenopus tadpole alternative model to study innate-like T cell-mediated anti-mycobacterial immunityR21AI139718 · NIAID · UNIVERSITY OF ROCHESTER · PI ROBERT, JACQUES · 2018 to 2019
$424k
Long-term effects of developmental exposure to a mixture of thyroid disruptors associated with hydrofracking on T cell development and antimicrobial immunityR21ES030690 · NIEHS · UNIVERSITY OF ROCHESTER · PI ROBERT, JACQUES · 2020 to 2021
$424k
NIAID NIH HHS R21 AI139718NIAID NIH HHS R24 AI059830NIEHS NIH HHS P30 ES001247NIEHS NIH HHS R21 ES030690NIEHS NIH HHS T32 ES007026
6 · The paper itself

Abstract

Immunity is susceptible to reprogramming by environmental chemical and endocrine signals. Notably, numerous thyroid disrupting chemicals (TDCs) have the potential to perturb immune endpoints, but data are lacking on the mechanisms by which TDCs can influence the development of the immune system. T cell immunity is particularly vulnerable to modulation by TDCs during thymic education, differentiation, and selection. The following review discusses the ways in which thyroid hormones may influence T cell development, as well as emerging TDCs with potential to impact both thyroid hormone physiology and immune outcomes. To overcome the challenges of studying TDC impacts on immune toxicological endpoints, a comparative approach using the amphibian Xenopus laevis is recommended. X. laevis are ideally suited to studying TDC impacts on immunity due to the importance of thyroid hormones for metamorphosis, and the wealth of immunological models to measure immune endpoints in both tadpoles and adult frogs.

Indexed as

Endocrine DisruptorsAnimalsCell DifferentiationLarvaMetamorphosis, BiologicalThyroid HormonesXenopus laevisEndocrine DisruptorsThyroid HormonesEndocrine disrupting chemicalsImmunotoxicityMetamorphosisPost-embryonic developmentT cellThymusThyroidXenopus

Identifiers

PMID36529309
PMCPMC9892850
OpenAlexW4313530716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.