Evidence map›Paper›PMID 36528974›Full record

ArticleDifferentiation; research in biological diversity

Retinoic acid signaling in mouse retina endothelial cells is required for early angiogenic growth.

Christina N Como, Cesar Cervantes, Brad Pawlikowski, Julie Siegenthaler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. Development of the blood-brain barrier.Development (Cambridge, England) · 2026
    Review
  4. Article
  5. Characterizing the lens regeneration process in Pleurodeles waltl.Differentiation; research in biological diversity
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christina N ComoUniversity of Colorado, Anschutz Medical Campus, Department of Pediatrics, Section of Developmental Biology, Aurora, CO, 80045, USA; University of Colorado, Anschutz Medical Campus, Neuroscience Graduate Program, Aurora, CO, 80045, USA; University of Colorado, Anschutz Medical Campus, Summer Research Training Program, Aurora, CO, 80045, USA.
Cesar CervantesUniversity of Colorado, Anschutz Medical Campus, Department of Pediatrics, Section of Developmental Biology, Aurora, CO, 80045, USA; University of Colorado, Anschutz Medical Campus, Summer Research Training Program, Aurora, CO, 80045, USA.
Brad PawlikowskiUniversity of Colorado, Anschutz Medical Campus, Department of Pediatrics, Section of Developmental Biology, Aurora, CO, 80045, USA.
Julie SiegenthalerUniversity of Colorado, Anschutz Medical Campus, Department of Pediatrics, Section of Developmental Biology, Aurora, CO, 80045, USA; University of Colorado, Anschutz Medical Campus, Neuroscience Graduate Program, Aurora, CO, 80045, USA; University of Colorado, Anschutz Medical Campus, Summer Research Training Program, Aurora, CO, 80045, USA. Electronic address: Julie.Siegenthaler@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · US

Funding

Retinoic Acid in Development of CNS VasculatureR01NS098273 · NINDS · UNIVERSITY OF COLORADO DENVER · PI SIEGENTHALER, JULIE · 2016 to 2025
$3.2M
Neuroscience Training GrantT32NS099042 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Nidia Calero, GIDON S FELSEN · 2016 to 2026
$2.1M
NINDS NIH HHS R01 NS098273NINDS NIH HHS T32 NS099042
6 · The paper itself

Abstract

The development of the retinal vasculature is essential to maintain health of the tissue, but the developmental mechanisms are not completely understood. The aim of this study was to investigate the cell-autonomous role of retinoic acid signaling in endothelial cells during retina vascular development. Using a temporal and cell-specific mouse model to disrupt retinoic acid signaling in endothelial cells in the postnatal retina (Pdgfb

Indexed as

Endothelial CellsTretinoinAnimalsMiceRetinaRetinal VesselsSignal TransductionTretinoinBlood-retinal barrierCNS angiogenesisEndothelial cellsRetinoic acidVEGFR3

Identifiers

PMID36528974
PMCPMC10006372
OpenAlexW4312114119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.