Predictors of persistent post-surgical pain intensity and interference at 1 year after breast cancer surgery: assessing central sensitization, central sensitivity symptoms, and psychological factors.

Masahiro Manfuku, Tomohiko Nishigami, Akira Mibu, Hirofumi Yamashita, Ryota Imai, Hiroe Kanamori, Kazuhiro Sumiyoshi

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Article in Breast cancer (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed

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6 citing papers in PubMed.

Multidimensional Recovery Trajectories Throughout Breast Cancer Treatment and Survivorship: A Prospective Longitudinal Study.Current oncology (Toronto, Ont.) · 2026
Article
Physical Therapy Utilization and Morbidity Outcomes After Breast Cancer Surgery: A Longitudinal Analysis of Three Combined Cohorts.Cancers · 2025
Article
Interference with activities of daily living according to pain level after breast surgery.Surgical oncology insight · 2024
Article
Association of Aromatase Inhibitor-Induced Musculoskeletal Symptoms with Central Sensitization-Related Symptoms: A Cross-Sectional Study.Breast care (Basel, Switzerland) · 2024
Article
Prognostic factors for the development of upper limb dysfunctions after breast cancer: the UPLIFT-BC prospective longitudinal cohort study protocol.BMJ open · 2024
Article
Central Sensitization in Cancer Survivors and Its Clinical Implications: State of the Art.Journal of clinical medicine · 2023
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7 authors.

Masahiro ManfukuDepartment of Rehabilitation, Breast Care Sensyu Clinic, Osaka, Japan.

Tomohiko NishigamiDepartment of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, Mihara , Hiroshima, Japan. tomon@pu-hiroshima.ac.jp.ORCID http://orcid.org/0000-0002-6969-8916

Akira MibuDepartment of Physical Therapy, Konan Women's University, Hyogo, Japan.

Hirofumi YamashitaDepartment of Rehabilitation, Nozomi Orthopaedic Clinic Saijo, Hiroshima, Japan.

Ryota ImaiGraduate School of Rehabilitation, Osaka Kawasaki Rehabilitation University, Osaka, Japan.

Hiroe KanamoriDepartment of Breast Surgery, Breast Care Sensyu Clinic, Osaka, Japan.

Kazuhiro SumiyoshiDepartment of Breast Surgery, Breast Care Sensyu Clinic, Osaka, Japan.

Funding

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6 · The paper itself

Abstract

backgroundPersistent post-surgical pain (PPSP) is associated with upper limb dysfunction and decreased quality of life and causes long-term suffering for breast cancer survivors after surgery. However, the predictors of PPSP remain unclear. The purpose of this study was to examine predictors of PPSP intensity and interference at 1 year postoperatively, focusing on treatment-related factors, pre- and postoperative central sensitization (CS), CS-related symptoms (e.g., muscle stiffness, fatigue, sleep disturbances), and psychological factors.

methodsEighty-eight women with planned unilateral breast cancer surgery were included in this longitudinal study. CS, CS-related symptoms, and psychological factors were assessed preoperatively, 1 month postoperatively, and 1 year postoperatively. Analysis of covariance was used to compare the groups with and without PPSP, accounting for treatment-related factors. Multiple regression analysis was performed to identify predictors of PPSP intensity and interference at 1 year postoperatively.

resultsEven after adjusting for covariates, preoperative and 1-month postoperative Central Sensitization Inventory scores in the PPSP group were significantly higher than scores in the group without PPSP. Multiple regression analysis showed that axillary lymph node dissection (ALND) and 1-month postoperative CS-related symptoms were independent predictors of PPSP intensity and interference at 1 year postoperatively (p < 0.01).

conclusionWe found that ALND and 1-month postoperative CS-related symptoms were predictors of PPSP intensity and interference at 1 year postoperatively.

Indexed as

Breast NeoplasmsCentral Nervous System SensitizationFemaleHumansLongitudinal StudiesPostoperative PainQuality of LifeBreast cancer survivorsCentral sensitivity symptomsCentral sensitizationPersistent post-surgical painPost mastectomy pain syndrome

Identifiers

PMID36528837

DOI10.18632/aging.202502

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