ArticleScientific reports2022
Mechanism underlying vascular remodeling in relation to circulating CD34-positive cells among older Japanese men.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 21 citations in OpenAlex.
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- Association Between Chronic Kidney Disease and Subclinical Hypothyroidism Categorized by Hypertension Status.Diseases (Basel, Switzerland) · 2026Article
- Subclinical hypothyroidism and height loss in relation to the status of thyroid cysts: a prospective study.Environmental health and preventive medicine · 2026Article
- Association between bedtime snacking and subclinical hypothyroidism.Environmental health and preventive medicine · 2026Article
- Anti-early antigen Epstein-Barr virus titer and atherosclerosis in relation to vascular endothelial growth factor (VEGF) polymorphism rs3025039 among older Japanese individuals.Environmental health and preventive medicine · 2025Article
- Subclinical hypothyroidism and height loss according to free thyroxine levels: a prospective study.Environmental health and preventive medicine · 2025Article
- Beneficial influence of low-density lipoprotein cholesterol on the endothelium in relation to endothelial repair.Environmental health and preventive medicine · 2025Article
- The impact of acute and chronic aerobic and resistance exercise on stem cell mobilization: A review of effects in healthy and diseased individuals across different age groups.Regenerative therapy · 2024Article
- Association between serum uric acid levels and cardio-ankle vascular index stratified by circulating level of CD34-positive cells among elderly Japanese men: a cross-sectional study.Scientific reports · 2024Article
- Association between eating speed and atherosclerosis in relation to growth differentiation factor-15 levels in older individuals in a cross-sectional study.Scientific reports · 2024Article
- SARS-CoV-2 Infection during Delivery Causes Histopathological Changes in the Placenta.Diseases (Basel, Switzerland) · 2024Article
- Association between underweight, serum albumin levels, and height loss in the Japanese male population: a retrospective study.Journal of physiological anthropology · 2024Article
- Association between atherosclerosis and height loss among older individuals.Scientific reports · 2024Article
- TGF-β Isoforms and GDF-15 in the Development and Progression of Atherosclerosis.International journal of molecular sciences · 2024Review
- Molecular Mechanisms Underlying Vascular Remodeling in Hypertension.Reviews in cardiovascular medicine · 2024Review
- Association between smoking and height loss in Japanese workers: A retrospective study.PloS one · 2024Article
- Platelet count and hypertension as indicators of height loss in the general population: A prospective study.PloS one · 2024Article
- Association between serum albumin levels and height loss in Japanese workers: a retrospective study.Journal of physiological anthropology · 2023Article
- Progression of Carotid Intima-Media Thickness Partly Indicates the Prevention of Hypertension among Older Individuals in the General Population.Life (Basel, Switzerland) · 2023Article
- Serum Concentration of Growth Differentiation Factor 15 and Atherosclerosis among General Older Japanese Individuals with Normal Weight.Biomedicines · 2023Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Development of structural atherosclerosis, an established cardiovascular risk factor, requires hematopoietic stem cells known as CD34-positive cells. However, an inverse association between circulating CD34-positive cell count and cardiovascular disease has been reported. These studies evoke a contradiction: characteristics associated with a low risk of developing structural atherosclerosis are also associated with a high risk of cardiovascular disease. To clarify the mechanisms underlying vascular remodeling, we conducted several epidemiological studies of Japanese men aged 60 to 69 years who participated in annual health check-ups. The present study summarizes those epidemiological studies and adds some discussion. From the perspective of endothelial repair activity, there are significant differences between functional versus structural atherosclerosis. Aggressive endothelial repair increases both functional and structural atherosclerosis. Deficient endothelial repair related to a shortage of CD34-positive cells due to consumption furthers functional atherosclerosis but not structural atherosclerosis. Therefore, the lack of structural atherosclerosis does not always reflect a favorable condition for the endothelium. Although further investigation is necessary, the present study suggests that higher endothelial repair activity that leads to structural atherosclerosis might have a beneficial effect on vascular health among older men.
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