Evidence map›Paper›PMID 36528473›Full record

Trial reportUrologic oncology2023

Quality of life for men with metastatic castrate-resistant prostate cancer participating in an aerobic and resistance exercise pilot intervention.

Crystal S Langlais, Yea-Hung Chen, Erin L Van Blarigan, June M Chan, Charles J Ryan, Li Zhang, Hala T Borno, Robert U Newton, Anthony Luke, Alexander S Bang and 11 more

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Urologic oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06451120 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Study of Platelet Rich Plasma (PRP) Injections With Symptomatic Knee Osteoarthritis for Biomarker Exploration in Young and Old Human Subjects

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2027Enrolled60ConditionsOsteoarthritis, Articular Cartilage, Musculoskeletal DisordersArmsPlatelet-Rich Plasma (PRP) Injections, Centrifuge, Control saline injection
NCT07032584 narecruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Multimodal Telerehabilitation on Reducing Disparities in Rural Survivors of Metastatic Prostate Cancer

TypeinterventionalSponsorUniversity of UtahRan2025 to 2029Enrolled74ConditionsProstate Cancer, Metastatic Prostate Cancer, Androgen Deprivation TherapyArmsTelerehabilitation Intervention
NCT07093177 narecruitingnot on this mapstarted 2026, after this paper: background citation

Multimodal Telerehabilitation of Rural Patients With Advanced Prostate Cancer

TypeinterventionalSponsorUniversity of UtahRan2026 to 2028Enrolled30ConditionsProstate CancerArmsTelerehabilitation Unit
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Crystal S LanglaisUniversity of California, San Francisco, CA.
Yea-Hung ChenUniversity of California, San Francisco, CA.
Erin L Van BlariganUniversity of California, San Francisco, CA.
June M ChanUniversity of California, San Francisco, CA.
Charles J RyanUniversity of California, San Francisco, CA.
Li ZhangUniversity of California, San Francisco, CA.
Hala T BornoUniversity of California, San Francisco, CA.
Robert U NewtonEdith Cowan University, Perth, Australia.
Anthony LukeUniversity of California, San Francisco, CA.
Alexander S BangUniversity of California, San Francisco, CA.
Neil PanchalUniversity of California, San Francisco, CA.
Imelda TenggaraUniversity of California, San Francisco, CA.
Brooke SchultzUniversity of California, San Francisco, CA.
Emil LavakiUniversity of California, San Francisco, CA.
Nicole PintoUniversity of California, San Francisco, CA.
Rahul AggarwalUniversity of California, San Francisco, CA.
Terence FriedlanderUniversity of California, San Francisco, CA.
Vadim S KoshkinUniversity of California, San Francisco, CA.
Andrea L HarzstarkKaiser Permanente Oakland Medical Center, Oakland, CA.
Eric J SmallUniversity of California, San Francisco, CA.
Stacey A KenfieldUniversity of California, San Francisco, CA. Electronic address: Stacey.Kenfield@ucsf.edu.

Funding

Diet After Colorectal Cancer : Observational Studies to Behavioral InterventionsK07CA197077 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAN BLARIGAN, ERIN LYNN · 2016 to 2020
$885k
A Randomized Clinical Trial of Exercise for Men with Metastatic Prostate CancerR21CA184605 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KENFIELD, STACEY · 2015 to 2016
$379k
Impact of Modifiable Diet and Lifestyle Factors on Prostate Cancer ProgressionF31CA247093 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGLAIS, CRYSTAL · 2020 to 2021
$54k
NCI NIH HHS F31 CA247093NCI NIH HHS K07 CA197077NCI NIH HHS R21 CA184605
6 · The paper itself

Abstract

backgroundFollowing a prostate cancer diagnosis, disease and treatment-related symptoms may result in diminished quality of life (QoL). Whether exercise improves QoL in men with metastatic castrate-resistant prostate cancer (mCRPC) is not fully understood.

methodsWe conducted a 3-arm pilot randomized controlled trial to assess the feasibility, acceptability, safety, and efficacy of a 12-week remotely monitored exercise program among men with mCRPC. Here we report qualitative changes in QoL, consistent with the guidelines for pilot trials. Men were randomized to control, aerobic exercise, or resistance exercise. Exercise prescriptions were based on baseline cardiorespiratory and strength assessments. QoL outcomes were evaluated using self-reported questionnaires (e.g., QLQ-C30, PROMIS Fatigue, Pittsburgh Sleep Quality Index (PSQI), EPIC-26) collected at baseline and 12 weeks.

resultsA total of 25 men were randomized (10 control, 8 aerobic, 7 resistance). Men were predominately white (76%) with a median age of 71 years (range: 51-84) and 10.5 years (range: 0.9-26.3) post prostate cancer diagnosis. The men reported poor sleep quality and high levels of fatigue at enrollment. Other baseline QoL metrics were relatively high. Compared to the controls at 12 weeks, the resistance arm reported some improvements in social function and urinary irritative/obstruction symptoms while the aerobic arm reported some improvements in social function and urinary incontinence, yet worsening nausea/vomiting. Compared to the resistance arm, the aerobic arm reported worse urinary irritative/obstruction symptoms and self-rated QoL, yet some improvements in emotional function, insomnia, and diarrhea.

conclusionsThe 3-month exercise intervention pilot appeared to have modest effects on QoL among mCRPC survivors on ADT. Given the feasibility, acceptability, and safety demonstrated in prior analyses, evaluation of the effect of the intervention on QoL in a larger sample and for extended duration may still be warranted.

Indexed as

Prostatic Neoplasms, Castration-ResistantResistance TrainingAgedAged, 80 and overFatigueHumansMaleMiddle AgedPilot ProjectsQuality of LifeBehavioral intervention: Physical activityRemoteStrength training

Identifiers

PMID36528473
PMCPMC13185653

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.