Evidence map›Paper›PMID 36528197›Full record

SynthesisEnvironmental pollution (Barking, Essex : 1987)2023

A systematic review of evidence for maternal preconception exposure to outdoor air pollution on Children's health.

Natalie Blanc, Jiawen Liao, Frank Gilliland, Junfeng Jim Zhang, Kiros Berhane, Guoying Huang, Weili Yan, Zhanghua Chen

Open access · greenAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Environmental pollution (Barking, Essex : 1987), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Maternal SOFrontiers in endocrinology · 2026
    Article
  5. Review
  6. FIGO committee opinion: Environmental drivers of obstetric health and early childhood development.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Natalie BlancUniversity of Southern California, Los Angeles, CA, USA.
Jiawen LiaoDepartment of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Frank GillilandDepartment of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Junfeng Jim ZhangDivision of Environmental Science and Policy, Nicholas School of the Environment, Duke University, Durham, NC, USA; Duke Global Health Institute, Durham, NC, USA.
Kiros BerhaneDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Guoying HuangChildren's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defect, Shanghai, China.
Weili YanChildren's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defect, Shanghai, China.
Zhanghua ChenDepartment of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address: zhanghuc@usc.edu.
University of Southern California · USChildren's Hospital of Fudan University · CNColumbia University · USDuke University · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Urban Air Pollution &Persistent Early Life AsthmaP01ES009581 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILLILAND, FRANK D. · 1999 to 2010
$6.8M
The Integrative Genomics of Acute Asthma ControlR01HL118455 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MILLSTEIN, JOSHUA, RABY, BENJAMIN ALEXANDER · 2014 to 2024
$6.5M
Impact of preconception and onward exposure to air pollution on growth trajectories of infants and children (R01)R01ES029945 · NIEHS · DUKE UNIVERSITY · PI GILLILAND, FRANK D., ZHANG, JUNFENG · 2019 to 2022
$2.0M
Metabolomic Signatures Linking Air Pollution, Obesity and DiabetesR00ES027870 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHANGHUA · 2019 to 2021
$747k
NHLBI NIH HHS R01 HL118455NIEHS NIH HHS P01 ES009581NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R00 ES027870NIEHS NIH HHS R01 ES029945
6 · The paper itself

Abstract

The preconception period is a critical window for gametogenesis, therefore preconception exposure to air pollutants may have long-term effects on children. We systematically reviewed epidemiological evidence concerning the effects of preconception ambient air pollution exposure on children's health outcomes and identified research gaps for future investigations. We searched PubMed and Web of Science from journal inception up to October 2022 based on an established protocol (PROSPERO: CRD42022277608). We then identified 162 articles based on searching strategy, 22 of which met the inclusion criteria. Studies covered a wide range of health outcomes including birth defects, preterm birth, birthweight, respiratory outcomes, and developmental outcomes. Findings suggested that exposure to outdoor air pollutants during maternal preconception period were associated with various health outcomes, of which birth defects has the most consistent findings. A meta-analysis revealed that during 3-month preconception period, a 10 μg/m

Indexed as

Air PollutantsAir PollutionChild HealthMaternal ExposurePreconception InjuriesPremature BirthBirth WeightChildEnvironmental ExposureFemaleHumansInfant, NewbornParticulate MatterAir PollutantsParticulate MatterAir pollutionBirth defectsBirthweightPreconceptionPreterm birth

Identifiers

PMID36528197
PMCPMC9879265
OpenAlexW4313201974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.