Evidence map›Paper›PMID 36527831›Full record

ReviewBiosensors & bioelectronics2023

Biosensor integrated tissue chips and their applications on Earth and in space.

Anne Yau, Zizheng Wang, Nadya Ponthempilly, Yi Zhang, Xueju Wang, Yupeng Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biosensors & bioelectronics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anne YauDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06296, USA.
Zizheng WangDepartment of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA.
Nadya PonthempillyDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06296, USA.
Yi ZhangDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06296, USA; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA. Electronic address: yi.5.zhang@uconn.edu.
Xueju WangDepartment of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA. Electronic address: xueju.wang@uconn.edu.
Yupeng ChenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06296, USA. Electronic address: yupeng.chen@uconn.edu.

Funding

Supplement: Developing Nanomaterial Platform for Intra-Cartilage Delivery of RNA Therapeutics against Joint DiseasesR01AR072027 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI CHEN, YUPENG · 2017 to 2022
$2.3M
Multifunctional 3D Bioelectronic and Microfluidic Hybrid Systems for Online Monitoring, Regulation, and Vascularization of OrganoidsR21EB033495 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, XUEJU · 2022 to 2024
$644k
Layer-by-Layer Nano Matrix for Growth Plate RegenerationR21AR079153 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI CHEN, YUPENG · 2022 to 2023
$393k
NIAMS NIH HHS R01 AR072027NIAMS NIH HHS R21 AR079153NIBIB NIH HHS R21 EB033495
6 · The paper itself

Abstract

The development of space exploration technologies has positively impacted everyday life on Earth in terms of communication, environmental, social, and economic perspectives. The human body constantly fluctuates during spaceflight, even for a short-term mission. Unfortunately, technology is evolving faster than humans' ability to adapt, and many therapeutics entering clinical trials fail even after being subjected to vigorous in vivo testing due to toxicity and lack of efficacy. Therefore, tissue chips (also mentioned as organ-on-a-chip) with biosensors are being developed to compensate for the lack of relevant models to help improve the drug development process. There has been a push to monitor cell and tissue functions, based on their biological signals and utilize the integration of biosensors into tissue chips in space to monitor and assess cell microenvironment in real-time. With the collaboration between the Center for the Advancement of Science in Space (CASIS), the National Aeronautics and Space Administration (NASA) and other partners, they are providing the opportunities to study the effects of microgravity environment has on the human body. Institutions such as the National Institute of Health (NIH) and National Science Foundation (NSF) are partnering with CASIS and NASA to utilize tissue chips onboard the International Space Station (ISS). This article reviews the endless benefits of space technology, the development of integrated biosensors in tissue chips and their applications to better understand human biology, physiology, and diseases in space and on Earth, followed by future perspectives of tissue chip applications on Earth and in space.

Indexed as

Biosensing TechniquesSpace FlightWeightlessnessHumansBiosensorsIn-space applicationsOrgan-on-a-chipTissue chipsTissue engineering

Identifiers

PMID36527831
PMCPMC10143284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.