Evidence map›Paper›PMID 36527657›Full record

ArticleAdvances in experimental medicine and biology2022

Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus.

Denis E Bragin, O A Bragina, F Monickaraj, A Noghero, A O Trofimov, E M Nemoto, M V Kameneva

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Denis E BraginLovelace Biomedical Research Institute, Albuquerque, NM, USA. dbragin@lovelacebiomedical.org.
O A BraginaLovelace Biomedical Research Institute, Albuquerque, NM, USA.
F MonickarajDepartment of Ophthalmology and Visual Sciences, University of New Mexico School of Medicine, Albuquerque, NM, USA.
A NogheroLovelace Biomedical Research Institute, Albuquerque, NM, USA.
A O TrofimovDepartment of Neurology, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
E M NemotoDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
M V KamenevaMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Biomedical Research Institute · USLovelace Respiratory Research Institute · USMcGowan Institute for Regenerative Medicine · USNew Mexico VA Health Care System · USPrivolzhsky Research Medical University · RUUniversity of New Mexico · US

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS112808
6 · The paper itself

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease characterised by hyperglycaemia and glucose intolerance caused by impaired insulin action and/or defective insulin secretion. Long-term hyperglycaemia leads to various structural and functional microvascular changes within multiple tissues, including the brain, which involves blood-brain barrier alteration, inflammation and neuronal dysfunction. We have shown previously that drag-reducing polymers (DRP) improve microcirculation and tissue oxygen supply, thereby reducing neurologic impairment in different rat models of brain injury. We hypothesised that DRP could improve cerebral and skin microcirculation in the situation of progressive microangiopathies associated with diabetes using a mouse model of diabetes mellitus. Diabetes was induced in C57BL/6 J mice with five daily consecutive intraperitoneal injections of streptozotocin (50 mg/kg/day). Animals with plasma glucose concentrations greater than 250 mg/dL were considered diabetic and were used in the study following four months of diabetes. DRP (2 ppm) was injected biweekly during the last two weeks of the experiment. Cortical and skin (ear) microvascular cerebral blood flow (mCBF) and tissue oxygen supply (NADH) were measured by two-photon laser scanning microscopy (2PLSM). Cerebrovascular reactivity (CVR) was evaluated by measuring changes in arteriolar diameters and NADH (tissue oxygen supply) during the hypercapnia test. Transient hypercapnia was induced by a 60-second increase of CO

Indexed as

Diabetes Mellitus, ExperimentalHyperglycemiaAnimalsDisease Models, AnimalHemodynamicsHypercapniaMiceMice, Inbred C57BLMicrocirculationNADOxygenPolymersRatsNADOxygenPolymersCapillary perfusionCerebrovascular reactivityGlucose intoleranceHyperglycemiaHypoxia

Identifiers

PMID36527657
PMCPMC10033219
OpenAlexW4312018414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.