Evidence map›Paper›PMID 36527655›Full record

ArticleAdvances in experimental medicine and biology2022

A Radiation Biological Analysis of the Oxygen Effect as a Possible Mechanism in FLASH.

Harold M Swartz, P Jack Hoopes, David J Gladstone, Valentin Demidov, Peter Vaupel, Ann Barry Flood, Benjamin B Williams, Rongxiao Zhang, Brian W Pogue

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Timescale of FLASH Sparing Effect Determined by Varying Temporal Split of Dose Delivery in Mice.International journal of radiation oncology, biology, physics · 2026
    Article
  2. Mechanisms of the FLASH effect: current insights and advances.Frontiers in cell and developmental biology · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Harold M SwartzGeisel School of Medicine, Dartmouth College, Hanover, NH, USA. harold.swartz@dartmouth.edu.
P Jack HoopesGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.
David J GladstoneGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Valentin DemidovGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Peter VaupelDepartment of Radiation Oncology, University Medical Center, Freiburg, Germany.
Ann Barry FloodGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Benjamin B WilliamsGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Rongxiao ZhangGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Brian W PogueGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Dartmouth College · USDartmouth–Hitchcock Medical Center · USUniversity Medical Center Freiburg · DE

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
NCI NIH HHS P30 CA023108
6 · The paper itself

Abstract

The delivery of radiation at an ultra-high dose rate (FLASH) is an important new approach to radiotherapy (RT) that appears to be able to improve the therapeutic ratio by diminishing damage to normal tissues. While the mechanisms by which FLASH improves outcomes have not been established, a role involving molecular oxygen (O

Indexed as

DNA DamageOxygenRadiotherapy DosageOxygenHypoxiaOxygen depletionRadiation resistanceRadiotherapy

Identifiers

PMID36527655
PMCPMC10653672
OpenAlexW4312018547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.