ArticleAdvances in experimental medicine and biology2022
Basic Examination of Haemoglobin Phase of Oxygenation and Deoxygenation in Resting State and Task Periods in Adults Using fNIRS.
Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technique used to measure the relative changes in concentrations of oxygenated haemoglobin (oxy-Hb) and deoxygenated haemoglobin (deoxy-Hb) in the cerebral cortex. While most previous studies using fNIRS have relied only on a single oxy-Hb or deoxy-Hb parameter to infer about neural activation, the phase difference between the oxy- and deoxy-Hb signals (haemoglobin phase of oxygenation and deoxygenation: hPod) has been reported to be an important biomarker for analysing haemodynamic characteristics of the brain in infants. In this study, we examined the basic characteristics of adult hPod to develop a new analysis method to detect more sensitive signals that reflect neural activation in adults using fNIRS. We measured the hPod of 12 healthy adults in the frontal and occipital cortex during rest and upon exposure to visual stimuli and the verbal working memory (WM) task. We found that the average hPod values during the entire measurement period ranged between π and 1.5π rad in all conditions. This result indicates that the phase differences in adults were generally close to a stable antiphase pattern (hPod values around π), regardless of the presence or absence of tasks and stimuli. However, when dynamic changes in hPod values were analysed, significant differences between the resting state and WM tasks were observed during activation period in the frontal and occipital regions. These results suggest that the analysis of dynamic hPod change is useful for detecting a subtle activation for cognitive tasks.
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