Evidence map›Paper›PMID 36527614›Full record

ArticleAdvances in experimental medicine and biology2022

NIRS-Based Study of Local Cerebral Oxygenation During Transcranial Direct Current Stimulation in Patients with Mild Traumatic Brain Injury.

Alex O Trofimov, Darya I Agarkova, Dmitry Sergeev, Anton Dubrovin, Kseniia A Trofimova, Oxana Novosadova, Dmitry Martynov, Kyril Lidji-Goryaev, Denis E Bragin

Open access · greenAbstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Alex O TrofimovDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Darya I AgarkovaDepartment of Polytrauma, Regional Hospital named after Semashko, Nizhny Novgorod, Russia.
Dmitry SergeevDepartment of Polytrauma, Regional Hospital named after Semashko, Nizhny Novgorod, Russia.
Anton DubrovinDepartment of Polytrauma, Regional Hospital named after Semashko, Nizhny Novgorod, Russia.
Kseniia A TrofimovaDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Oxana NovosadovaDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Dmitry MartynovState Technical University named after R.E. Alekseev, Nizhny Novgorod, Russia.
Kyril Lidji-GoryaevDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Denis E BraginLovelace Biomedical Research Institute, Albuquerque, NM, USA.
Nizhny Novgorod Regional Clinical Hospital named after Semashko · RUPrivolzhsky Research Medical University · RUBiomedical Research Institute · USNizhny Novgorod State Pedagogical University · RU

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS112808
6 · The paper itself

Abstract

The purpose of our study was to assess the dynamics of local cerebral oxygenation (LCO) by near-infrared spectroscopy (NIRS) during transcranial direct current stimulation (tDCS) in the acute stage of mild traumatic brain injury (mTBI). Fifty-seven mTBI patients (18 women and 39 men, 35 ± 11.7 years old, GCS 13.7 ± 0.7) were treated by tDCS at 3-5 days after head injury. Stimulation parameters were: 1 mA, 9 V, duration-20 min. A cerebral oximeter was used to assess LCO-values in the frontotemporal lobes. Anodal and cathodal LCO values were compared before tDCS and every 2 min until the tDCS end. Significance was preset to p < 0.05. Results: A significant decrease in LCO values on the anodal side was observed at the 8th to 12th minutes of stimulation, compared to the cathodal side (at 8th minute - p = 0.011; at 12th minute - p < 0.00000001) and compared to LCO values before tDCS (p < 0.00001). The LCO on the cathodal side was not significantly different during the whole tDCS. At the end of the procedure, the interhemispheric LCO differences were not statistically significant (p = 0.757). Conclusions: Transcranial DCS in 3-5 days of mTBI leads to a significant decrease in the LCO value on the anodal side between 8 and 12 min and subsequent recovery to baseline values by the end of the procedure.

Indexed as

Brain ConcussionTranscranial Direct Current StimulationAdultCerebrovascular CirculationElectrodesFemaleHumansMaleMiddle AgedSpectroscopy, Near-InfraredYoung AdultLocal cerebral oxygenationMild traumatic brain injuryNeurovascular couplingTranscranial direct current stimulation

Identifiers

PMID36527614
PMCPMC10042479
OpenAlexW4312018726

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.