Evidence map›Paper›PMID 36527613›Full record

ArticleAdvances in experimental medicine and biology2022

Photomodulation of Lymphatic Delivery of Bevacizumab to the Brain: The Role of Singlet Oxygen.

Oxana Semyachkina-Glushkovskaya, Sergey Diduk, Eroshova Anna, Dosadina Elina, Kruglov Artem, Alexander Khorovodov, Alexander Shirokov, Ivan Fedosov, Alexander Dubrovsky, Inna Blokhina and 9 more

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Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Oxana Semyachkina-GlushkovskayaHumboldt University, Berlin, Germany.
Sergey DidukPushchino State Institut of Natural Science, Moscow, Russia.
Eroshova AnnaPushchino State Institut of Natural Science, Moscow, Russia.
Dosadina ElinaPushchino State Institut of Natural Science, Moscow, Russia.
Kruglov ArtemPushchino State Institut of Natural Science, Moscow, Russia.
Alexander KhorovodovSaratov State University, Saratov, Russia.
Alexander ShirokovSaratov State University, Saratov, Russia.
Ivan FedosovSaratov State University, Saratov, Russia.
Alexander DubrovskySaratov State University, Saratov, Russia.
Inna BlokhinaSaratov State University, Saratov, Russia.
Andrey TerskovSaratov State University, Saratov, Russia.
Georgy KarandinSaratov State University, Saratov, Russia.
Arina EvsukovaSaratov State University, Saratov, Russia.
Anna TsvenSaratov State University, Saratov, Russia.
Valeria TelnovaSaratov State University, Saratov, Russia.
Ilana AfranovichSaratov State University, Saratov, Russia.
Sergey SokolovskiPhysics Department, Humboldt University, Berlin, Germany.
Edik RafailovPhysics Department, Humboldt University, Berlin, Germany.
Jürgen KurthsHumboldt University, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. Therefore, the development of safe methods for an effective delivery of medications to the brain can be a revolutionary step in overcoming this limitation. Using a quantum-dot-based 1267 nm laser (photosensitiser-free generation of singlet oxygen), we clearly show the photostimulation of lymphatic delivery of bevacizumab (BMZ) to the brain tissues and the meninges. These pilot findings open promising perspectives for photomodulation of a lymphatic brain drug delivery bypassing the BBB, and potentially enabling a breakthrough strategy in therapy of glioma using BMZ and other chemotherapy drugs.

Indexed as

Lymphatic VesselsSinglet OxygenBevacizumabBlood-Brain BarrierBrainDrug Delivery SystemsBevacizumabSinglet OxygenBlood-brain barrierGlymphaticsLymphaticsMeningeal lymphatic vesselsPhotostimulation

Identifiers

PMID36527613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.