ArticleAdvances in experimental medicine and biology2022
Brain Tissue Conductivity in Focal Cerebral Ischemia.
Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Machine learning enhanced noninvasive transcranial stroke detection using a portable eddy current damping sensor.iScience · 2025Article
- Repeatability and Reproducibility Uncertainty in Magnetic Resonance-Based Electric Properties Tomography of a Homogeneous Phantom.Tomography (Ann Arbor, Mich.) · 2023Article
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4 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral ischemia leads to oxygen depletion with rapid breakdown of transmembrane transporters and subsequent impaired electrolyte haemostasis. Electric properties tomography (EPT) is a new contrast in MRI which delivers information on tissue electrical conductivity. In the clinical realm it has been mostly used for tumour mapping. Ischemic cerebral stroke is another promising but neglected application. It might deliver additional information on tissue viability and possible response to therapy.
aimThe aim of this study was to demonstrate tissue conductivity in a rodent model of stroke. Further, we aimed to compare electric conductivity in ischemic and non-ischemic cerebral tissue. MATERIALS AND
methodsTwo male Wistar rats were used in this study and were subjected to permanent MCAO. The animals were scanned in a 3 Tesla system (Philips Achieva/Best, the Netherlands) using a dedicated solenoid animal coil (Philips/Hamburg, Germany). In addition to diffusion weighted imaging (DWI), EPT was performed using a steady-state free-precession (SSFP) sequence (repetition time/echo time = 4.5/2.3 ms, measured voxel size = 0.6 × 0.6 × 1.2 mm
resultsThe animals exhibited an infarct as demonstrated on DWI. Conductivity within the infarcted region was 60-70 % of the conductivity of not affected contralateral tissue (0.39 ± 0.07 S/m and 0.31 ± 0.14 S/m vs. 0.64 ± 0.15 S/m and 0.66 ± 0.16 S/m, respectively). DISCUSSION: Infarcted tissue exhibited decreased conductivity. Further in-vivo experiments with examination of the influence of reperfusion status and temporal evolution of the infarcted areas should be conducted. Depiction of the ischemic penumbra and possibly subclassification of the DWI lesion still seems to be a fruitful target for further studies.
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