ArticleEpilepsia2023
Intrinsic and secondary epileptogenicity in focal cortical dysplasia type II.
Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Complementing Engel Classification: Postoperative Scalp EEG as an Objective Indicator in SEEG-Guided Radiofrequency Thermocoagulation-A Seizure-Onset Pattern-Based Stratified Analysis.Annals of clinical and translational neurology · 2026Article
- Mosaic human cortical organoids model mTOR-related focal cortical dysplasia through DEPDC5 deletion.Brain : a journal of neurology · 2026Article
- Seizure occurrence in FCD type II is predicted by lesion position and linked to cytoarchitectural alterations.Acta neuropathologica communications · 2025Article
- Intraoperative magnetic resonance imaging during surgical resection for drug resistant epilepsy eliminates the incidence of inadvertent incomplete resection of the epileptogenic zone and early surgical failure.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia.Nature neuroscience · 2025Article
- ILAE genetic literacy series: Focal cortical dysplasia.Epileptic disorders : international epilepsy journal with videotape · 2025Review
- Expansion of epileptogenic networks via neuroplasticity in neural mass models.PLoS computational biology · 2024Article
- Normative atlases of high-frequency oscillation and spike rates under Sevoflurane anesthesia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Establishment of a normal control model of children's brain 18-fluorodeoxyglucose positron emission tomography and analysis of the changing pattern in patients aged 0-14 years.Quantitative imaging in medicine and surgery · 2024Article
- Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy.Nature neuroscience · 2024Article
- Hypometabolic patterns are related to post-surgical seizure outcomes in focal cortical dysplasia: A semi-quantitative study.Epilepsia open · 2024Article
- Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI study.Frontiers in neuroscience · 2024Article
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Abstract
objectiveFavorable seizure outcome is reported following resection of bottom-of-sulcus dysplasia (BOSD). We assessed the distribution of epileptogenicity and dysplasia in and around BOSD to better understand this clinical outcome and the optimal surgical approach.
methodsWe studied 27 children and adolescents with magnetic resonance imaging (MRI)-positive BOSD who underwent epilepsy surgery; 85% became seizure-free postresection (median = 5.0 years follow-up). All patients had resection of the dysplastic sulcus, and 11 had additional resection of the gyral crown (GC) or adjacent gyri (AG). Markers of epileptogenicity were relative cortical hypometabolism on preoperative
resultsRelative cortical metabolism was significantly reduced and ECoG markers were significantly increased at the BOS compared to other regions. Apart from spiking and PAC, which were greater at the TOS compared to the GC, there were no significant differences in PET and other ECoG markers between the TOS, GC, and AG, suggesting a cutoff of epileptogenicity at the TOS rather than a tapering gradient on the cortical surface. MRI and tissue markers of dysplasia were all maximal in the BOS, reduced in the TOS, and mostly absent in the GC. Spiking and PAC reduced significantly over the GC after resection of the dysplastic sulcus. SIGNIFICANCE: These findings support the concept that dysplasia and intrinsic epileptogenicity are mostly limited to the dysplastic sulcus in BOSD and support resection or ablation confined to the MRI-visible lesion as a first-line surgical approach.
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