Evidence map›Paper›PMID 36527333›Full record

ArticleAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine2023

Rural and socioeconomic differences in the effectiveness of the HEART Pathway accelerated diagnostic protocol.

James C O'Neill, Nicklaus P Ashburn, Brennan E Paradee, Anna C Snavely, Jason P Stopyra, Greg Noe, Simon A Mahler

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In one paragraph

Article in Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Rural and socioeconomic differences in the effectiveness of the HEART Pathway accelerated diagnostic protocol.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James C O'NeillDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-2080-3981
Nicklaus P AshburnDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-3466-8813
Brennan E ParadeeDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Anna C SnavelyDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jason P StopyraDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0001-7457-3969
Greg NoeDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Simon A MahlerDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-2199-4078

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
CVD Epidemiology Training ProgramT32HL076132 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAVID McLeod HERRINGTON · 2004 to 2026
$8.4M
Wake Forest Clinical and Translational Science AwardKL2TR001421 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MILLER, DAVID P · 2015 to 2023
$5.8M
NCATS NIH HHS KL2 TR001421NCATS NIH HHS UL1 TR001420NHLBI NIH HHS L30 HL120008NHLBI NIH HHS T32 HL076132
6 · The paper itself

Abstract

backgroundThe HEART Pathway is a validated accelerated diagnostic protocol (ADP) for patients with possible acute coronary syndrome (ACS). This study aimed to compare the safety and effectiveness of the HEART Pathway based on patient rurality (rural vs. urban) or socioeconomic status (SES).

methodsWe performed a preplanned subgroup analysis of the HEART Pathway Implementation Study. The primary outcomes were death or myocardial infarction (MI) and hospitalization at 30 days. Proportions were compared by SES and rurality with Fisher's exact tests. Logistic regression evaluated for interactions of ADP implementation with SES or rurality and changes in outcomes within subgroups.

resultsAmong 7245 patients with rurality and SES data, 39.9% (2887/7245) were rural and 22.2% were low SES (1607/7245). The HEART Pathway identified patients as low risk in 32.2% (818/2540) of urban versus 28.1% (425/1512) of rural patients (p = 0.007) and 34.0% (311/915) of low SES versus 29.7% (932/3137) high SES patients (p = 0.02). Among low-risk patients, 30-day death or MI occurred in 0.6% (5/818) of urban versus 0.2% (1/425) rural (p = 0.67) and 0.6% (2/311) with low SES versus 0.4% (4/932) high SES (p = 0.64). Following implementation, 30-day hospitalization was reduced by 7.7% in urban patients (adjusted odds ratio [aOR] 0.76, 95% confidence interval [CI] 0.66-0.87), 10.6% in low SES patients (aOR 0.68, 95% CI 0.54-0.86), and 4.5% in high SES patients (aOR 0.83, 95% CI 0.73-0.94). However, rural patients had a nonsignificant 3.3% reduction in hospitalizations.

conclusionsHEART Pathway implementation decreased 30-day hospitalizations regardless of SES and for urban patients but not rural patients. The 30-day death or MI rate was similar among low-risk patients.

Indexed as

Acute Coronary SyndromeMyocardial InfarctionHospitalizationHumansRisk FactorsRural PopulationSocioeconomic Factors

Identifiers

PMID36527333
PMCPMC10009897

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.