Evidence map›Paper›PMID 36527143›Full record

Trial reportTrials2022

Oral vitamin D supplemental therapy to attain a desired serum 25-hydroxyvitamin D concentration in essential healthcare teams.

Banafshe Hosseini, Cécile L Tremblay, Cristina Longo, Shirin Glochi, John H White, Caroline Quach, Louis-Georges Ste-Marie, Robert W Platt, Francine M Ducharme

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04483635 (PROTECT RCT), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04483635 phase3terminatednot on this map

PROTECT RCT (PRevention of COVID-19 With Oral Vitamin D Supplemental Therapy in Essential healthCare Teams

TypeinterventionalSponsorSt. Justine's HospitalRan2021 to 2021Enrolled34ConditionsCOVID-19ArmsPlacebo, Vitamin D
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Banafshe HosseiniClinical Research and Knowledge Transfer Unit On Childhood Asthma, Research Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada.
Cécile L TremblayDepartment of Microbiology, Infectious Disease and Immunology, Centre Hospitalier Universitaire de Montréal, University of Montreal, Quebec, Canada.
Cristina LongoClinical Research and Knowledge Transfer Unit On Childhood Asthma, Research Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada.
Shirin GlochiDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
John H WhiteDepartments of Physiology and Medicine, McGill University, Montreal, QC, Canada.
Caroline QuachDepartment of Microbiology, Infectious Diseases and Immunology, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Quebec, Canada.
Louis-Georges Ste-MarieDepartment of Medicine, Centre Hospitalier Universitaire de Montréal, Montreal, QC, Canada.
Robert W PlattDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Francine M DucharmeClinical Research and Knowledge Transfer Unit On Childhood Asthma, Research Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada. francine.m.ducharme@umontreal.ca.ORCID http://orcid.org/0000-0001-5096-0614
Centre Hospitalier Universitaire Sainte-Justine · CAMcGill University · CACentre Hospitalier de l’Université de Montréal · CA

Funding

CIHR 447317
6 · The paper itself

Abstract

backgroundThe study objectives were to ascertain the efficacy of vitamin D supplementation in rapidly increasing serum vitamin D and of implementation of a hybrid (virtual and in-person) trial.

methodsIn a randomized triple-blind controlled trial, healthcare workers were allocated to receive an oral bolus of 100,000 IU with 10,000 IU/week of vitamin D

resultsThirty-four (19 intervention, 15 control) subjects were randomized, with 28 (41%) virtual visits. After 44.78 ± 11.00 days from baseline, a significant adjusted group difference of 44.2 (34.7, 53.8) nmol/L was observed in the Δ 25(OH)D (95% CI) in favor of supplementation; 77.8% of intervention, and 13.3% of control, patients were vitamin D sufficient (OR:6.11, 95% CI:1.6, 22.9). The adherence to intervention was 94.7% in the intervention and 100% in the control groups. Irrespective of visit type, high adherence was observed in sampling procedures and completion of fortnightly online questionnaire. No adverse events attributable to vitamin D were reported.

conclusionThe vitamin D supplementation rapidly and safely raised 25(OH)D levels to sufficient levels for a biological effect. Similarly high adherence to study procedures was observed with virtual and in-person participation.

trial registrationThis trial was registered at https://clinicaltrials.gov on July 23, 2020 (# NCT04483635 ).

Indexed as

Vitamin DVitamin D DeficiencyCalcifediolCholecalciferolDietary SupplementsDouble-Blind MethodHumansPatient Care TeamVitamins25-hydroxyvitamin DCalcifediolCholecalciferolVitamin DVitaminsHealthcare workersHybrid studyRandomized controlled trialVitamin D

Identifiers

PMID36527143
PMCPMC9756469
OpenAlexW4311687287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.