ArticleBMC infectious diseases2022
Clinical and epidemiologic evaluation of a 2020 chikungunya outbreak in Cambodia.
Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 16 citations in OpenAlex.
- Development and validation of an interpretable machine learning model for early hospital-based differentiation of chikungunya and dengue fever using routine clinical data.BMC infectious diseases · 2026Observational
- Genomic surveillance reveals multiple origins and local transmission of travel-associated chikungunya virus in Yunnan, China.BMC microbiology · 2026Article
- Chikungunya outbreak in eastern Senegal, 2023.BMC infectious diseases · 2026Article
- Proof-of-Concept Machine Learning Framework for Arboviral Disease Classification Using Literature-Derived Synthetic Data: Methodological Development Preceding Clinical Validation.Healthcare (Basel, Switzerland) · 2026Article
- Identification of a TCR signature in peripheral blood derived CD4+ T cells, associated with chronic chikungunya disease, suggests a conducive, female-biased, background immune profile.Frontiers in immunology · 2026Article
- Article
- Clinical Manifestations, Risk Factors, and Disease Burden of Rickettsiosis, Cambodia, 2007-2020.Emerging infectious diseases · 2025Review
- Clinical Presentation, Risk Factors, and Comparison of Laboratory Diagnostics for Seasonal Influenza Virus Among Cambodians From 2007 to 2020.Open forum infectious diseases · 2024Article
- The Chikungunya virus: A reemerging cause of acute febrile illness in the high jungle of northern Peru.PLoS neglected tropical diseases · 2023Article
- National dengue surveillance, Cambodia 2002-2020.Bulletin of the World Health Organization · 2023Article
- Longitudinal Study of Viral Diversity Associated with Mosquito Species Circulating in Cambodia.Viruses · 2023Article
- Mosquito diversity (Diptera: Culicidae) and medical importance in four Cambodian forests.Parasites & vectors · 2023Article
- Serological and molecular evidence of chikungunya virus infection among febrile outpatients seeking healthcare in Northern Malawi.Infection ecology & epidemiology · 2023Article
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Authors and funding
12 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn 2020, the Kingdom of Cambodia experienced a nationwide outbreak of chikungunya virus (CHIKV). Despite an increase in the frequency of outbreaks and expanding geographic range of CHIKV, diagnostic challenges remain, and limited surveillance data of sufficient granularity are available to characterize epidemiological profiles and disease dynamics of the virus.
methodsAn ongoing and long-standing cross-sectional study of acute undifferentiated febrile illness (AUFI) in Cambodia was leveraged to describe the disease epidemiology and characterize the clinical presentation of patients diagnosed with CHIKV during the 2020 outbreak. Participants presenting with AUFI symptoms at ten study locations provided acute and convalescent blood samples and were tested for CHIKV using a reverse transcription-polymerase chain reaction (RT-PCR) and serological diagnostic methods including IgM and IgG. Acute and follow-up clinical data were also collected.
resultsFrom 1194 participant blood samples tested, 331 (27.7%) positive CHIKV cases were detected. Most CHIKV positive individuals (280, 84.6%) reported having a fever 3 to 4 days prior to visiting a health facility. Symptoms including chills, joint pain, nausea, vomiting, and lesions were all statistically significant among CHIKV positive participants compared to CHIKV negative AUFI participants. Cough was negatively associated with CHIKV positive participants. Positivity proportions were significantly higher among adults compared to children. No significant difference was found in positivity proportion between rainy and dry seasons during the outbreak. Positive CHIKV cases were detected in all study site provinces, with the highest test positivity proportion recorded in the rural northeast province of Kratie.
conclusionsSurveillance data captured in this study provided a clinical and epidemiological characterization of positive CHIKV patients presenting at selected health facilities in Cambodia in 2020, and highlighted the widespread distribution of the outbreak, impacting both urban and rural locations. Findings also illustrated the importance of utilizing both RT-PCR and serological testing for effective CHIKV surveillance.
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