Evidence map›Paper›PMID 36526616›Full record

ArticleNature communications2022

Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19.

Hideki Ogura, Jin Gohda, Xiuyuan Lu, Mizuki Yamamoto, Yoshio Takesue, Aoi Son, Sadayuki Doi, Kazuyuki Matsushita, Fumitaka Isobe, Yoshihiro Fukuda and 10 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 1 country.

Hideki OguraDepartment of Microbiology, Hyogo Medical University, Hyogo, Japan. hi-ogura@hyo-med.ac.jp.ORCID 0000-0002-2116-0340
Jin GohdaResearch Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Xiuyuan LuLaboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan.ORCID 0000-0002-0784-2871
Mizuki YamamotoResearch Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-3731-1702
Yoshio TakesueDepartment of Infection Control and Prevention, Hyogo Medical University, Hyogo, Japan.ORCID 0000-0002-8635-6416
Aoi SonDepartment of Microbiology, Hyogo Medical University, Hyogo, Japan.ORCID 0000-0002-5387-0187
Sadayuki DoiKawanishi City Hospital, Hyogo, Japan.
Kazuyuki MatsushitaKyoritsu Hospital, Hyogo, Japan.
Fumitaka IsobeKyowa Marina Hospital/Wellhouse Nishinomiya, Hyogo, Japan.
Yoshihiro FukudaDainikyoritsu Hospital, Hyogo, Japan.
Tai-Ping HuangKyoritsu Onsen Hospital, Hyogo, Japan.
Takamasa UenoJoint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.ORCID 0000-0003-4852-4236
Naomi MamboDepartment of Emergency and Critical Care Medicine, Hyogo Medical University, Hyogo, Japan.
Hiromoto MurakamiDepartment of Emergency and Critical Care Medicine, Hyogo Medical University, Hyogo, Japan.
Yasushi KawaguchiResearch Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-8232-6925
Jun-Ichiro InoueResearch Platform Office, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-6389-7036
Kunihiro ShiraiDepartment of Emergency and Critical Care Medicine, Hyogo Medical University, Hyogo, Japan.
Sho YamasakiLaboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan.ORCID 0000-0002-5184-6917
Jun-Ichi HirataDepartment of Emergency and Critical Care Medicine, Hyogo Medical University, Hyogo, Japan.
Satoshi IshidoDepartment of Microbiology, Hyogo Medical University, Hyogo, Japan. sh-ishido@hyo-med.ac.jp.ORCID 0000-0001-5893-3354
Hyogo University · JPNational Institute of Infectious Diseases · JPHiroshima Kyoritsu Hospital · JPKumamoto University · JPKyushu University · JPThe University of Osaka · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the importance of virus-specific cytotoxic T lymphocytes (CTL) in virus clearance is evident in COVID-19, the characteristics of virus-specific CTLs related to disease severity have not been fully explored. Here we show that the phenotype of virus-specific CTLs against immunoprevalent epitopes in COVID-19 convalescents might differ according to the course of the disease. We establish a cellular screening method that uses artificial antigen presenting cells, expressing HLA-A

Indexed as

CD8-Positive T-LymphocytesCOVID-19Epitopes, T-LymphocyteHLA-A AntigensHumansSARS-CoV-2T-Lymphocytes, CytotoxicEpitopes, T-LymphocyteHLA-A Antigens

Identifiers

PMID36526616
PMCPMC9758236
OpenAlexW4313236922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.