Evidence map›Paper›PMID 36526596›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy.

Di Wen, Tingxizi Liang, Guojun Chen, Hongjun Li, Zejun Wang, Jinqiang Wang, Ruxing Fu, Xiao Han, Tianyuan Ci, Yuqi Zhang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Orchestration of Tumor-Associated Macrophages in the Tumor Cell-Macrophage-CD8International journal of biological sciences · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Di WenDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Tingxizi LiangDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Guojun ChenDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Hongjun LiDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Zejun WangDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Jinqiang WangDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Ruxing FuDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Xiao HanDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Tianyuan CiDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Yuqi ZhangDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Peter AbdouDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Ruoxin LiDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Linlin BuDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Gianpietro DottiDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zhen GuDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.ORCID 0000-0003-2947-4456
University of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · US

Funding

Platelets-Mediated Delivery of Checkpoint Inhibitors for Post-Surgical Cancer ImmunotherapyR01CA234343 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2023
$2.0M
Cellular Immunotherapy of Ovarian CancerR01CA243543 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOTTI, GIANPIETRO · 2019 to 2023
$2.0M
NCI NIH HHS R01 CA234343NCI NIH HHS R01 CA243543NIH HHS R01 CA234343-01A1
6 · The paper itself

Abstract

Tumor-associated adipocytes (TAAs) recruit monocytes and promote their differentiation into tumor-associated macrophages (TAMs) that support tumor development. Here, TAAs are engineered to promote the polarization of TAMs to the tumor suppressive M1 phenotype. Telratolimod, a toll-like receptor 7/8 agonist, is loaded into the lipid droplets of adipocytes to be released at the tumor site upon tumor cell-triggered lipolysis. Locally administered drug-loaded adipocytes increased tumor suppressive M1 macrophages in both primary and distant tumors and suppressed tumor growth in a melanoma model. Furthermore, drug-loaded adipocytes improved CD8

Indexed as

MelanomaTumor-Associated MacrophagesAdipocytesHumansImmunotherapyMacrophagesTumor Microenvironmentadipocytecancer immunotherapydrug deliverymacrophage

Identifiers

PMID36526596
PMCPMC9929126
OpenAlexW4311824876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.