ReviewSeminars in cell & developmental biology
Evolution of the insect Hox gene cluster: Comparative analysis across 243 species.
Review in Seminars in cell & developmental biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- High-quality whole genome data ofData in brief · 2025Article
- Genomic resources for the scuttle fly Megaselia abdita: a model organism for comparative developmental studies in flies.Development (Cambridge, England) · 2025Article
- In Vivo Models of Cardiovascular Disease:Biomedicines · 2025Review
- Divergent Hox cluster collinearity in horned beetles reveals adult head patterning function of labial.Developmental biology · 2025Article
- The Earth BioGenome Project Phase II: illuminating the eukaryotic tree of life.Frontiers in science · 2025Article
- Unbiased anchors for reliable genome-wide synteny detection.Algorithms for molecular biology : AMB · 2025Article
- Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network.Integrative and comparative biology · 2024Review
- Problems with Paralogs: The Promise and Challenges of Gene Duplicates in Evo-Devo Research.Integrative and comparative biology · 2024Review
- Article
- High-quality haploid genomes corroborate 29 chromosomes and highly conserved synteny of genes in Hyles hawkmoths (Lepidoptera: Sphingidae).BMC genomics · 2023Article
- The genome sequence of the variegated flesh fly,Wellcome open research · 2023Article
- The genome sequence of the White-backed Marble,Wellcome open research · 2023Article
- Hox genes: The original body builders.Seminars in cell & developmental biologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Hox gene cluster is an iconic example of evolutionary conservation between divergent animal lineages, providing evidence for ancient similarities in the genetic control of embryonic development. However, there are differences between taxa in gene order, gene number and genomic organisation implying conservation is not absolute. There are also examples of radical functional change of Hox genes; for example, the ftz, zen and bcd genes in insects play roles in segmentation, extraembryonic membrane formation and body polarity, rather than specification of anteroposterior position. There have been detailed descriptions of Hox genes and Hox gene clusters in several insect species, including important model systems, but a large-scale overview has been lacking. Here we extend these studies using the publicly-available complete genome sequences of 243 insect species from 13 orders. We show that the insect Hox cluster is characterised by large intergenic distances, consistently extreme in Odonata, Orthoptera, Hemiptera and Trichoptera, and always larger between the 'posterior' Hox genes. We find duplications of ftz and zen in many species and multiple independent cluster breaks, although certain modules of neighbouring genes are rarely broken apart suggesting some organisational constraints. As more high-quality genomes are obtained, a challenge will be to relate structural genomic changes to phenotypic change across insect phylogeny.
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