Evidence map›Paper›PMID 36526428›Full record

Trial reportNeurology2023

Supportive Self-Management Program for People With Chronic Headaches and Migraine: A Randomized Controlled Trial and Economic Evaluation.

Martin Underwood, Felix Achana, Dawn Carnes, Sandra Eldridge, David R Ellard, Frances Griffiths, Kirstie Haywood, Siew Wan Hee, Helen Higgins, Dipesh Mistry and 13 more

Open access · hybridAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 6 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 6 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  9. Psychological interventions for migraine.Nature reviews. Neurology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 2 institutions in 1 country.

Martin UnderwoodFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom. m.underwood@warwick.ac.uk.
Felix AchanaFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Dawn CarnesFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Sandra EldridgeFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
David R EllardFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.ORCID 0000-0002-2992-048X
Frances GriffithsFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Kirstie HaywoodFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.ORCID 0000-0002-5405-187X
Siew Wan HeeFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.ORCID 0000-0002-0415-263X
Helen HigginsFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Dipesh MistryFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Hema MistryFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.ORCID 0000-0002-5023-1160
Sian NewtonFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Vivien NicholsFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Chloe NormanFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Emma PadfieldFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.ORCID 0000-0003-4832-9609
Shilpa PatelFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Stavros PetrouFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Tamar PincusFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Rachel PotterFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Harbinder SandhuFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Kimberley StewartFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Stephanie J C TaylorFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.ORCID 0000-0001-7454-6354
Manjit S MatharuFrom the Warwick Clinical Trials Unit (M.U., F.A., D.E., H.H., D.M., H.M., V.N., C.N., E.P., S.P., R.P., H.S., K.S.), and Division of Health Sciences (F.G., K.H., S.W.H.), Warwick Medical School University of Warwick, Coventry; University Hospitals Coventry and Warwickshire (M.U., D.E., H.M.), Coventry; University College of Osteopathy (D.C.), London; Wolfson Institute of Population Health (S.E., S.N., S.J.C.T.), Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Nuffield Department of Primary Care Health Sciences (S.P.), University of Oxford; Department of Psychology (T.P.), Royal Holloway University of London; and Headache Group Institute of Neurology (M.S.M.) and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
University of Warwick · GBUniversity Hospitals Coventry and Warwickshire NHS Trust · GB

Funding

Department of Health RP-PG-1212-20018
6 · The paper itself

Abstract

BACKGROUND AND

objectivesChronic headache disorders are a major cause of pain and disability. Education and supportive self-management approaches could reduce the burden of headache disability. We tested the effectiveness of a group educational and supportive self-management program for people living with chronic headaches.

methodsThis was a pragmatic randomized controlled trial. Participants were aged 18 years or older with chronic migraine or chronic tension-type headache, with or without medication overuse headache. We primarily recruited from general practices. Participants were assigned to either a 2-day group education and self-management program, a one-to-one nurse interview, and telephone support or to usual care plus relaxation material. The primary outcome was headache related-quality of life using the Headache Impact Test (HIT)-6 at 12 months. The primary analysis used intention-to-treat principles for participants with migraine and both baseline and 12-month HIT-6 data.

resultsBetween April 2017 and March 2019, we randomized 736 participants. Because only 9 participants just had tension-type headache, our main analyses were on the 727 participants with migraine. Of them, 376 were allocated to the self-management intervention and 351 to usual care. Data from 586 (81%) participants were analyzed for primary outcome. There was no between-group difference in HIT-6 (adjusted mean difference = -0.3, 95% CI -1.23 to 0.67) or headache days (0.9, 95% CI -0.29 to 2.05) at 12 months. The Chronic Headache Education and Self-management Study intervention generated incremental adjusted costs of £268 (95% CI, £176-£377) (USD383 [95% CI USD252-USD539]) and incremental adjusted quality-adjusted life years (QALYs) of 0.031 (95% CI -0.005 to 0.063). The incremental cost-effectiveness ratio was £8,617 (USD12,322) per QALY gained. DISCUSSION: These findings conclusively show a lack of benefit for quality of life or monthly headache days from a brief group education and supportive self-management program for people living with chronic migraine or chronic tension-type headache with episodic migraine. TRIAL REGISTRATION INFORMATION: Registered on the International Standard Randomized Controlled Trial Number registry, ISRCTN79708100 16th December 2015 doi.org/10.1186/ISRCTN79708100. The first enrollment was April 24, 2017. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that a brief group education and self-management program does not increase the probability of improvement in headache-related quality of life in people with chronic migraine.

Indexed as

Headache DisordersMigraine DisordersSelf-ManagementTension-Type HeadacheCost-Benefit AnalysisHeadacheHumansQuality of Life

Identifiers

PMID36526428
PMCPMC10065208
OpenAlexW4311822528

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