ArticleOsteoarthritis and cartilage2023
Improved responsiveness to change in joint space width over 24-month follow-up: comparison of 3D JSW on weight-bearing CT vs 2D JSW on radiographs in the MOST study.
Article in Osteoarthritis and cartilage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Longitudinal 3D quantification of joint space from CT images: Semi-automatic segmentation and feasibility of nnU-Net automation.Osteoarthritis imaging · 2026Article
- High-Fidelity Measurement-Based Detection Values and Roles of Three-Dimensional Joint Space Width in Evaluation of Knee Osteoarthritis.Orthopaedic surgery · 2026Article
- Review
- Baseline 3D joint space width on weight-bearing CT in comparison with 2D JSWOsteoarthritis imaging · 2026Article
- Usefulness of 3D joint space width on weight-bearing CT in comparison with 2D joint space width on radiographs for predicting 24-month worsening of knee osteoarthritis pain and function in the MOST study.Osteoarthritis and cartilage · 2026Article
- Article
- Weight-bearing computed tomography in knee pathologies: current evidence and future perspectives.Frontiers in surgery · 2026Review
- Trends in the Use of Weightbearing Computed Tomography.Journal of clinical medicine · 2024Review
- Semi-quantitative weight-bearing assessment of knee osteoarthritis: COAKS (CT Osteoarthritis Knee Score) reliability.Osteoarthritis imaging · 2024Article
- Quantitative assessment of the knee joint from weight bearing computed tomography.Osteoarthritis imaging · 2024Article
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Authors and funding
12 authors.
Funding
Abstract
objectiveRadiographic joint space width (JSW) has been a standard for measuring knee osteoarthritis (OA) structural change. Limitations in the responsiveness of this approach might be overcome by instead measuring 3D JSW on weight-bearing CT (WBCT). This study compared the responsiveness of 3D JSW measurements using WBCT with the responsiveness of radiographic 2D JSW.
designStanding, fixed-flexion knee radiographs (XR) and WBCT were acquired ancillary to the 144- and 168-month Multicenter Osteoarthritis Study visits. Tibiofemoral JSW was measured on both XR and WBCT. Responsiveness to change was defined by the standardized response mean (SRM) for change in JSW (1) at predetermined mediolateral locations (JSWx) on both modalities and (2) in the following subregions measured on WBCT images: central medial and lateral femur (CMF/CLF) and tibia (CMT/CLT), and anterior and posterior tibia (AMT/ALT, PMT/MLT).
resultsBaseline and 24-month follow-up JSWx measurements were completed for 265 participants (58.1% women). Responsiveness of 3D JSWx for medial tibiofemoral compartment on coronal WBCT (SRM range: -0.18, -0.24) exceeded that for 2D JSWx (-0.10, -0.16). Responsiveness of 3D JSW subregional mean (-0.06, -0.36) and maximal (-1.14, -1.75) CMF and CMT and maximal CLF/CLT 3D JSW changes were statistically significantly greater in comparison with respective medial and lateral 2D JSWx (P ≤ 0.002).
conclusionsSubregional 3D JSW on WBCT is substantially more responsive to 24-month changes in tibiofemoral joint structure compared to radiographic measurements. Use of subregional 3D JSW on WBCT could enable improved detection of OA structural progression over a 24-month duration in comparison with measurements made on XR.
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