Evidence map›Paper›PMID 36526022›Full record

ArticleAnalytical biochemistry2023

Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to K

Ian R Fleming, Jonathan P Hannan, George Hayden Swisher, Corey D Tesdahl, Justin G Martyr, Nicholas J Cordaro, Annette H Erbse, Joseph J Falke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3KγbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ian R FlemingMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, CO, 80309-0596, USA.
Jonathan P HannanMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, CO, 80309-0596, USA.
George Hayden SwisherMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, CO, 80309-0596, USA.
Corey D TesdahlMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, CO, 80309-0596, USA.
Justin G MartyrMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, CO, 80309-0596, USA.
Nicholas J CordaroMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, CO, 80309-0596, USA.
Annette H ErbseMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, CO, 80309-0596, USA.
Joseph J FalkeMolecular Biophysics Program and Department of Biochemistry, University of Colorado, Boulder, CO, 80309-0596, USA. Electronic address: falke@colorado.edu.
University of Colorado Boulder · US

Funding

Mechanisms of Signaling on Membrane SurfacesR01GM063235 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2001 to 2021
$6.4M
Predoctoral Training Molecular BiophysicsT32GM065103 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2002 to 2021
$4.3M
Mechanisms of Signaling on Membrane SurfacesR35GM144346 · NIGMS · UNIVERSITY OF COLORADO · PI JOSEPH J FALKE · 2022 to 2026
$2.0M
NIGMS NIH HHS R01 GM063235NIGMS NIH HHS R35 GM144346NIGMS NIH HHS T32 GM065103
6 · The paper itself

Abstract

Ras family GTPases (H/K/N-Ras) modulate numerous effectors, including the lipid kinase PI3K (phosphatidylinositol-3-kinase) that generates growth signal lipid PIP

Indexed as

Phosphatidylinositol 3-Kinasesras ProteinsGuanosine TriphosphatePhosphatidylinositolsProtein BindingGuanosine TriphosphatePhosphatidylinositol 3-KinasesPhosphatidylinositolsras ProteinsGMPPNGMPPNPGTPHRas GTPaseProtein-nucleotide complexRas small G protein

Identifiers

PMID36526022
PMCPMC9884175
OpenAlexW4312085611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.