Evidence map›Paper›PMID 36525953›Full record

ArticleMolecular cell2022

Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates.

Yulong Wei, Ya-Chi Ho

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Role of Monocyte/Macrophages in the Pathogenesis of NeuroHIV.Results and problems in cell differentiation · 2024
    Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yulong WeiDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Ya-Chi HoDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA. Electronic address: ya-chi.ho@yale.edu.
Yale University · US

Funding

BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination ImmunotherapyUM1AI164570 · NIAID · WISTAR INSTITUTE · PI Luis J Montaner, James L. Riley · 2021 to 2026
$34.7M
CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral DynamicsU54AI170856 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CHRISTOPHER P. HILL · 2022 to 2026
$34.4M
REACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9M
The Y-SCORCH Data Generation Center at Yale for Single-Cell Opioid Responses in the Context of HIVUM1DA051410 · NIDA · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, KLUGER, YUVAL · 2020 to 2025
$15.3M
Virus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI BJORKMAN, PAMELA J · 2019 to 2021
$14.9M
High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 3P01AI169768 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Ya-Chi Ho, Jonathan Li · 2022 to 2026
$10.1M
M-SCORCH: Methamphetamine use disorder data generation center for Single Cell Opioid Responses in the Context of HIVU01DA053628 · NIDA · YALE UNIVERSITY · PI HO, YA-CHI, SESTAN, NENAD · 2021 to 2025
$9.5M
The HUSH complex in HIV-1 latencyR37AI147868 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JEREMY LUBAN · 2019 to 2026
$6.4M
Role of clonal expansion in HIV-1 persistenceR01AI141009 · NIAID · YALE UNIVERSITY · PI Ya-Chi Ho · 2018 to 2026
$5.3M
T cell-targeted lentiviral vectors with Cas9/RNP for the in vivo gene therapy of HIV-AIDSR01AI145164 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI · 2019 to 2024
$3.7M
A Big Data Approach to Identify Epigenetic, Transcriptomic, and Network Dynamics as Immune Dysfunction Drivers Associated with HIV Infection and Substance Use DisorderR01DA051906 · NIDA · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER · 2020 to 2024
$2.8M
Evaluating the role of opioid medication assisted therapies in HIV-1 Persistence for persons living with HIV and opioid use disordersR61DA047037 · NIDA · YALE UNIVERSITY · PI HO, YA-CHI, KLUGER, YUVAL · 2018 to 2020
$2.3M
NIAID NIH HHS P01 AI169768NIAID NIH HHS P50 AI150464NIAID NIH HHS R01 AI141009NIAID NIH HHS R01 AI145164NIAID NIH HHS R37 AI147868NIAID NIH HHS U54 AI170856NIAID NIH HHS UM1 AI164565NIAID NIH HHS UM1 AI164570NIDA NIH HHS R01 DA051906NIDA NIH HHS R33 DA047037NIDA NIH HHS R61 DA047037NIDA NIH HHS U01 DA053628NIDA NIH HHS UM1 DA051410
6 · The paper itself

Abstract

Plaza-Jennings et al. applied single-nucleus RNA-seq, sorted neuronal and microglia cells for HiC, and found that chronic HIV infection in the brain induces interferon stimulation in microglia, drives chromatin reconfiguration into a transcriptionally active environment, and changes HIV integration landscape.

Indexed as

HIV InfectionsChromatinHumansInflammationInterferonsMicrogliaChromatinInterferons

Identifiers

PMID36525953
PMCPMC9925257
OpenAlexW4311759258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.