Evidence map›Paper›PMID 36525636›Full record

ArticleBiochemistry2023

Transient-State Kinetic Analysis of the RNA Polymerase II Nucleotide Incorporation Mechanism.

Zachariah I Carter, Ruth Q Jacobs, David A Schneider, Aaron L Lucius

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Biochemical characterization ofJournal of bacteriology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zachariah I CarterDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama35233, United States.
Ruth Q JacobsDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama35233, United States.ORCID 0000-0002-7854-7941
David A SchneiderDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama35233, United States.ORCID 0000-0003-0635-5091
Aaron L LuciusDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama35233, United States.ORCID 0000-0001-8636-5411
University of Alabama at Birmingham · US

Funding

ZINC DIETARY ALTERATIONS OF CADMIUM INDUCED HEPATIC TOXICITY IN RATSS06GM008111 · NIGMS · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI REAMS, ROMONIA RENEE · 1989 to 2008
$9.1M
Training Program in Cell, Molecular, and Developmental BiologyT32GM008111 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 1985 to 2022
$5.4M
UNDERSTANDING THE ROLES OF RNA POLYMERASE I IN TRANSCRIPTION AND BEYONDR35GM140710 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2021 to 2025
$2.1M
UAB Predoctoral Training Grant in Translational and Molecular SciencesT32GM109780 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PATEL, RAKESH P. · 2015 to 2019
$967k
NIGMS NIH HHS R35 GM140710NIGMS NIH HHS S06 GM008111NIGMS NIH HHS T32 GM008111NIGMS NIH HHS T32 GM109780
6 · The paper itself

Abstract

Eukaryotic RNA polymerase II (Pol II) is an essential enzyme that lies at the core of eukaryotic biology. Due to its pivotal role in gene expression, Pol II has been subjected to a substantial number of investigations. We aim to further our understanding of Pol II nucleotide incorporation by utilizing transient-state kinetic techniques to examine Pol II single nucleotide addition on the millisecond time scale. We analyzed

Indexed as

NucleotidesRNA Polymerase IIAdenosine TriphosphateKineticsRNA Polymerase ISaccharomyces cerevisiaeAdenosine TriphosphateNucleotidesRNA Polymerase IRNA Polymerase II

Identifiers

PMID36525636
PMCPMC10069233
OpenAlexW4311823989

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.